Results 21 to 30 of about 55,295 (265)

Pharmacokinetics of Flunixin and Tolfenamic Acid in Experimental Endotoxemic Awassi Sheep. [PDF]

Vet Med Sci
Endotoxemia was induced in the sheep in the group by administering 10 µg/kg of E. coli O55:B5 (LPS) toxin (via IV infusion in 30 mL of 0.9% NaCl over 30 min). The studies in the FM and TA groups were conducted according to a two‐stage crossover pharmacokinetic design, taking into account a 15‐day washout period between treatment periods ...
Altinok-Yipel F, Corum O, Durna Corum D, Turk E, Yildiz R, Guvenc M, Ilhan A, Uney K.   +7 more
europepmc   +2 more sources

The microcirculation during endotoxemia [PDF]

Cardiovascular Research, 1996
The initial responses to endotoxemia are detectable in the microcirculation as a microvascular inflammatory response characterized by activation of the endothelium stimulating these cells from their normal anticoagulant state to a procoagulant state with increased adhesiveness for leukocytes and platelets.
R S, McCuskey, R, Urbaschek, B, Urbaschek   +2 more
openaire   +2 more sources

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

Marine Drugs, 2014
An important problem of treating patients with endotoxemia is to find drugs to reduce the negative effects of endotoxin on the organism. We tested fucoidan (sulfated polysaccharide) from the brown alga Fucus evanescens as a potential drug in a mouse ...
Tatyana A. Kuznetsova, Natalya N. Besednova, Larisa M. Somova, Natalya G. Plekhova   +3 more
doaj   +1 more source

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. [PDF]

, 2014
Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory
Arimatsu, Kei, Gotoh, Kazuyoshi, Iida, Tetsuya, Minagawa, Takayoshi, Miyazawa, Haruna, Motooka, Daisuke, Nakajima, Mayuka, Nakamura, Shota, Ryder, Mark I, Yamada, Hitomi, Yamazaki, Kazuhisa   +10 more
core   +2 more sources

Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice

Gut Microbes, 2021
Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis ...
Yujie Shi, Yixin Zou, Yonghong Xiong, Shiyao Zhang, Mingming Song, Xiaofei An, Chang Liu, Wenxiang Zhang, Siyu Chen   +8 more
doaj   +1 more source

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]

, 2006
Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz, Barry BE, Bevilacqua MP, Body SC, Brunk DK, Deuel TF, Dore M, Feuerhake F, Forde RC, Frenette PS, Greenberg AW, Handa K, Hattori R, Heffner JE, Kai Heckel, Kiefmann R, Kubes P, Kubo H, Kuebler WM, Kuhnle GE, Kuhnle GE, Kuklin V, Leo R, Ley K, Li N, Martina Dörger, Massberg S, Matsui NM, Okada Y, Parish CR, Piccardoni P, Rainer Kiefmann, Rinko LJ, Rodgers SD, Ruf A, Sonja Schenkat, Wang L, Williams MJ   +37 more
core   +1 more source

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Respiratory Research, 2018
Background ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion ...
Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand, Cornelius J. Busch   +4 more
doaj   +1 more source

Clinical response in dogs with acute hemorrhagic diarrhea syndrome following randomized probiotic treatment or fecal microbiota transplant

Frontiers in Veterinary Science, 2023
Probiotics and fecal microbiota transplants (FMTs) are two microbiome-targeted therapies that have been investigated for use in gastrointestinal diseases associated with dysbiosis.
Maria C. Jugan, Kate KuKanich, Leah Freilich   +2 more
doaj   +1 more source

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs [PDF]

, 2017
Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists.
A Clauss, A Gatt, A Tripodi, A Zambruni, AF Riddell, AO Spiel, B Agarwal, B Agarwal, B Agarwal, DJ Antoine, DJ Antoine, E Gehrie, EA Sankey, FB Mayr, GC Hugenholtz, H Schochl, HJ Tsai, J Vaquero, JG O’Grady, JH Griffin, KC Lee, KC Lee, L Rinaldi, LA Baker, M Habib, M Senzolo, M Yamaguchi, MJ McPhail, P Chowdary, R Jalan, R Kanel von, RT Stravitz, RT Stravitz, SJ Deventer van, SJ Munoz, SR Ostrowski, T Lisman, T Lisman, TE Warkentin, V Rewari   +39 more
core   +4 more sources