Results 11 to 20 of about 55,295 (265)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Frontiers in Immunology, 2021
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS).
Shireen Mohammad, Christoph Thiemermann
doaj   +1 more source

Progression of the Wei-Qi-Ying-Xue syndrome, microcirculatory disturbances, in infectious diseases and treatment with traditional Chinese medicine

World Journal of Traditional Chinese Medicine, 2022
Lipopolysaccharide (LPS)-induced endotoxemia is a critical condition that initiates microcirculatory disturbance and may progress to multiple organ failure that threatens the lives of millions of people around the world each year.
Jing-Yan Han, Quan Li, Chun-Shui Pan, Kai Sun, Jing-Yu Fan   +4 more
doaj   +1 more source

Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population

BMC Immunology, 2022
Background Excessive inflammatory response is the primary cause of early death in patients with endotoxemia. Interleukin 22 (IL-22) has been shown to play critical roles in the modulation of infectious diseases, but its function in regulating immune ...
Chang Yu, Qihua Ling, Junzhe Jiao, Juhong Liu, Zhihua Huang, Fang Wang, Xuehua Sun, Xiaoni Kong   +7 more
doaj   +1 more source

Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival

Frontiers in Physiology, 2018
Sepsis syndrome is the most important cause of mortality in critically ill patients admitted to intensive care units (ICUs). However, current therapies for its prevention and treatment are still unsatisfactory, and the mortality rate is still high.
Alejandro Vallejos, Alejandro Vallejos, Pedro Olivares, Diego Varela, Diego Varela, Cesar Echeverria, Cesar Echeverria, Claudio Cabello-Verrugio, Claudio Cabello-Verrugio, Claudio Pérez-Leighton, Felipe Simon, Felipe Simon   +11 more
doaj   +1 more source

Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys

Journal of Veterinary Internal Medicine, 2020
Background Little information is available about endotoxemia in donkeys. Characterizing the systemic inflammatory response (SIRS) to lipopolysaccharide (LPS) in donkeys would provide valuable clinical and therapeutic information. The effects of meloxicam
Francisco Javier Mendoza Garcia, Carlos Gonzalez‐De Cara, Raul Aguilera‐Aguilera, Antonio Buzon‐Cuevas, Alejandro Perez‐Ecija   +4 more
doaj   +1 more source

Development and Characterization of an Endotoxemia Model in Zebra Fish

Frontiers in Immunology, 2018
Endotoxemia is a condition in which endotoxins enter the blood stream and cause systemic and sometimes lethal inflammation. Zebra fish provides a genetically tractable model organism for studying innate immunity, with additional advantages in live ...
Alan Y. Hsu, Theodore Gurol, Tiago J. P. Sobreira, Sheng Zhang, Sheng Zhang, Natalie Moore, Chufan Cai, Zhong-Yin Zhang, Zhong-Yin Zhang, Zhong-Yin Zhang, Zhong-Yin Zhang, Qing Deng, Qing Deng, Qing Deng   +13 more
doaj   +1 more source

Endotoxemia in Patients with Liver Cirrhosis

Aktualʹnaâ Infektologiâ, 2015
There is a relationship between infection and the severity of endotoxemia in patients with liver cirrhosis (LC). Bacterial or viral or agent, penetrating the body of a patient with LC, triggers a cascade of immune-enzymatic reactions resulting in the ...
O.N. Domashenko, N.V. Maksimtseva, D.S. Paniieva, D.M. Popova   +3 more
doaj   +1 more source

Bifidobacterium animalis subsp. lactis MN-Gup protects mice against gut microbiota-related obesity and endotoxemia induced by a high fat diet

Frontiers in Nutrition, 2022
Obesity has become a public health concern due to its global prevalence and high risk of complications such as endotoxemia. Given the important role of gut microbiota in obesity, probiotics targeting gut microbiota have been developed and applied to ...
Xiaokang Niu, Nana Zhang, Shusen Li, Ning Li, Ran Wang, Qi Zhang, Jingjing He, Erna Sun, Xiaohong Kang, Jing Zhan   +9 more
doaj   +1 more source

Beta-glucan reflects liver injury after preservation and transplantation in dogs. [PDF]

, 1999
Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend
Azoulay D, Bion JF, Blanot S, Clavien PA, Goto M, Hamilton G, Hodes DS, Kambayashi J, Kikuchi M, Levin J, Miyata T, Ruiz-Herrera J., Shuji Matsura, Starzl TE, Steininger R, Tadashi Katsuramaki, Tomomi Suzuki,, , Tanaka S, The Iwanaga S., Todo S, Yokoyama I, Yoshioka T, Zhang GH, Zhang GH, Zhu Y   +23 more
core   +1 more source