Glycocalyx in Endotoxemia and Sepsis [PDF]
The American Journal of Pathology, 2020 Along with the recognition of a crucial role played by endothelial dysfunction secondarily igniting cardiovascular, pulmonary, and renal complications, investigational focus has extended toward endothelial glycocalyx. This delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production ...
Michael S, Goligorsky, Dong, Sun
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The microcirculation during endotoxemia [PDF]
Cardiovascular Research, 1996 The initial responses to endotoxemia are detectable in the microcirculation as a microvascular inflammatory response characterized by activation of the endothelium stimulating these cells from their normal anticoagulant state to a procoagulant state with increased adhesiveness for leukocytes and platelets.
R S, McCuskey +2 more
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Immunotherapy of endotoxemia and septicemia
Immunobiology, 1993 Neutralization of endotoxin (lipopolysaccharide, LPS) would be of considerable benefit in the treatment of Gram-negative sepsis. Administration of anti-LPS antibodies is an old approach which has been renewed by improvements in monoclonal antibody technology.
Baumgartner JD, Glauser MP
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Mechanism for development of systemic endotoxemia in patients with cirrhosis and portal endotoxemia
Kanzo, 1980 肝硬変患者の末梢エンドトキシン血症出現の機序を知る為に,肝硬変20例,非硬変7例に経皮経肝カテーテル法を用い門脈系(門脈本幹,上腸間膜静脈,脾静脈)と末梢の血液を同時に採血しエンドトキシンを測定した.門脈系血でのエンドトキシン検出率は,肝硬変,非硬変例共に上腸間膜静脈血で高く,エンドトキシン濃度は,肝硬変例の方が非硬変例に比して高い傾向にあった.門脈系血中エンドトキシン陽性の肝硬変例のうち末梢での血中エンドトキシン陽性群は,陰性群に比してICG 15分停滞率の高値,肝内短絡路の増加がみられた.即ち肝硬変患者の末梢エンドトキシン血症の出現は,有効肝血流量の減少に起因する肝の細網内皮系機能低下により門脈血液中のエンドトキシンの除去ができないためと考えられた.
KOHNO, Kunihiko +5 more
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NHWD-870, a Potent BET Inhibitor, Ameliorated Endotoxemia-Induced Hepatic Inflammation via Suppression of BRD4-STAT1 Signaling and Macrophage M1 Polarization. [PDF]
J Inflamm ResZhou N +7 more
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Pharmacokinetics of Flunixin and Tolfenamic Acid in Experimental Endotoxemic Awassi Sheep. [PDF]
Vet Med SciAltinok-Yipel F +7 more
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Natural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives. [PDF]
MoleculesŠantić R +7 more
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Metformin improves endotoxemia and alters folliculogenesis in women with polycystic ovary syndrome. [PDF]
Endocr ConnectTrzcinski M +9 more
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Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review. [PDF]
MicrocirculationMatias EF +2 more
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