Results 1 to 10 of about 55,238 (209)

Endotoxemia is associated with an adverse metabolic profile

Innate Immunity, 2021
Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately
Anne-Mari Määttä, Aino Salminen, Milla Pietiäinen   +2 more
exaly   +2 more sources

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice [PDF]

PLoS ONE, 2013
To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic ...
Hernando Gomez, Patricia Loughran, Timothy R Billiar   +2 more
exaly   +2 more sources

Effects of Endotoxemia and Blood Pressure on Microcirculation and Noradrenaline Needs With or Without Dexmedetomidine in Beagle Dogs—A Blinded Cross-Over Study [PDF]

Animals
Endotoxemia often leads to microcirculatory derangement. In six sevoflurane anaesthetized Beagle dogs, we investigated the effects of 1 mg/kg of Escherichia coli lipopolysaccharide endotoxin intravenous and blood pressure (mean arterial pressure of 65 ...
Barbara Steblaj, Fabiola Binia Joerger, Sonja Hartnack, Angela Briganti, Annette P. N. Kutter   +4 more
doaj   +2 more sources

Unraveling the Role of Metabolic Endotoxemia in Accelerating Breast Tumor Progression [PDF]

Biomedicines
Background: Obese women have a significantly higher risk of bearing breast tumors that are resistant to therapies and are associated with poorer prognoses/treatment outcomes.
Daniela Nahmias Blank, Ofra Maimon, Esther Hermano, Emmy Drai, Ofer Chen, Aron Popovtzer, Tamar Peretz, Amichay Meirovitz, Michael Elkin   +8 more
doaj   +2 more sources

JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

Frontiers in Immunology, 2021
Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury.
Ling Chen, Xiaolin Zhong, Wenyu Cao, Mingli Mao, Wei Li, Hui Yang, Menglin Li, Mengmeng Shi, Yuan Zhang, Yincheng Deng, Xuyu Zu, Jianghua Liu   +11 more
doaj   +1 more source

Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in Endotoxemia

Frontiers in Pharmacology, 2021
Endotoxemia is characterized by initial uncontrollable inflammation, terminal immune paralysis, significant cell apoptosis and tissue injury, which can aggravate or induce multiple diseases and become one of the complications of many diseases. Therefore,
Zixuan Liu, Zixuan Liu, Wenxiang Wang, Wenxiang Wang, Jie Luo, Jie Luo, Yingrui Zhang, Yingrui Zhang, Yunsen Zhang, Zhiqiang Gan, Zhiqiang Gan, Xiaofei Shen, Yi Zhang, Yi Zhang, Xianli Meng   +14 more
doaj   +1 more source

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Translocation of lipopolysaccharide from gram‐negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and ...
Jaakko Leskelä, Iiro Toppila, Mari‐Anne Härma, Teemu Palviainen, Aino Salminen, Niina Sandholm, Milla Pietiäinen, Elisa Kopra, Jean‐Paul Pais de Barros, Mariann I. Lassenius, Anmol Kumar, Valma Harjutsalo, Kajsa Roslund, Carol Forsblom, Anu Loukola, Aki S. Havulinna, Laurent Lagrost, Veikko Salomaa, Per‐Henrik Groop, Markus Perola, Jaakko Kaprio, Markku Lehto, Pirkko J. Pussinen   +22 more
doaj   +1 more source

Glycocalyx in Endotoxemia and Sepsis [PDF]

The American Journal of Pathology, 2020
Along with the recognition of a crucial role played by endothelial dysfunction secondarily igniting cardiovascular, pulmonary, and renal complications, investigational focus has extended toward endothelial glycocalyx. This delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production ...
Michael S, Goligorsky, Dong, Sun
openaire   +2 more sources

Metabolic endotoxemia is dictated by the type of lipopolysaccharide

Cell Reports, 2021
Summary: Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize
Fernando F. Anhê, Nicole G. Barra, Joseph F. Cavallari, Brandyn D. Henriksbo, Jonathan D. Schertzer   +4 more
doaj   +1 more source

Anthropometric indices, lipid profile, and lipopolysaccharide-binding protein levels in metabolic endotoxemia: A case-control study in Calabar Metropolis, Nigeria

Journal of Acute Disease, 2020
Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia.
Ekong Raymond Eworo, Edmund Richard Egbe, Zibril A Okhormhe, Bassey K Offor, Bassey Ikoedem Uduak, Andeshongkwe Dauda   +5 more
doaj   +1 more source