Results 91 to 100 of about 54,513 (224)

Melatonin attenuates oxidative stress and modulates inflammatory response after experimental burn trauma [PDF]

, 2018
Introduction. Thermal injury activates an inflammatory response. Melatonin possesses anti-oxidant and anti-inflammatory properties. The objective of the present work was to study melatonin effects on the inflammatory response under ...
Atanasova, Milena, Bekyarova, Ganka, Hristova, Minka, Tzaneva, Maria   +3 more
core   +3 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. [PDF]

, 2014
At least a third of the blood supply in the world is used to transfuse 1-2 units of packed red blood cells for each intervention and most clinical trials of blood substitutes have been carried out at this level of oxygen carrying capacity (OCC ...
Acharya, Seetharama A, Cabrales, Pedro, Intaglietta, Marcos, Kistler, Erik B, Salazar Vázquez, Beatriz Y, Subramaniam, Shankar, Tartakovsky, Daniel M, Tsai, Amy G   +7 more
core   +3 more sources

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

LASER THERAPY FOR MANAGEMENT OF CEREBRAL DYSFUNCTION IN CASES OF ACUTE SEVERE PANCREATITIS

Неотложная медицинская помощь, 2018
Background. A persistently high mortality rate of patients with pancreatitis is the result of multiple organ failure which is in many aspects associated with developing endogenous intoxication.
A. P. Vlasov, D. Y. Timoshkin, M. A. Spirina, I. A. Chigakova, T. I. Vlasova, T. A. Muratova   +5 more
doaj   +1 more source

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]

, 2015
The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M, Costanzo, Anne, Gareau, Melanie G, Jameson, Julie M, Johnson, Andrew MF, Olefsky, Jerrold M, Quehenberger, Oswald   +6 more
core   +2 more sources

Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts

International Journal of Cancer, Volume 158, Issue 7, Page 1801-1812, 1 April 2026.
What's new? Disruption of the gut–liver axis has been suggested to play an important role in liver carcinogenesis. However, limited prospective research has explored associations between potentially harmful gut‐derived bacterial products and liver cancer risk.
Cody Z. Watling, Peter T. Campbell, Barry I. Graubard, Yanyu Wang, Andrew T. Gewirtz, Xuehong Zhang, Matthew J. Barnett, Julie E. Buring, Yu Chen, A. Heather Eliassen, J. Michael Gaziano, Jonathan N. Hofmann, Wen‐Yi Huang, Jae H. Kang, Jill Koshiol, Erikka Loftfield, I‐Min Lee, Steven C. Moore, Lorelei A. Mucci, Marian L. Neuhouser, Christina C. Newton, Mark P. Purdue, Howard D. Sesso, Martha Shrubsole, Rashmi Sinha, Lesley Tinker, Matthew Triplette, Caroline Y. Um, Kala Visvanathan, Eleanor L. Watts, Jean Wactawski‐Wende, Walter Willett, Fen Wu, Wei Zheng, Dinesh Barupal, Jessica L. Petrick, Katherine A. McGlynn   +36 more
wiley   +1 more source

Pathophysiological aspects of blood transfusion for patients with liver cirrhosis

Вестник хирургии имени И.И. Грекова, 2019
To date, there are no clear indications and reasons for transfusion therapy in patients with cirrhosis. The article discusses the basic pathophysiological changes in the patient’s body during the formation of the liver cirrhosis as the outcome of ...
E. Iu. Lazareva, A. V. Koloskov
doaj   +1 more source

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. [PDF]

, 2019
The gastrointestinal (GI) tract can play a critical role in the development of pathologies associated with overeating, overweight and obesity. We previously observed that supplementation with anthocyanins (AC) (particularly glycosides of cyanidin and ...
Adamo, Ana M, Cremonini, Eleonora, Daveri, Elena, Fraga, Cesar G, Hester, Shelly N, Kalanetra, Karen, Mastaloudis, Angela, Mills, David, Oteiza, Patricia I, Wood, Steve M   +9 more
core   +2 more sources