Results 71 to 80 of about 55,295 (265)

Heat Sepsis Precedes Heat Toxicity in the Pathophysiology of Heat Stroke—A New Paradigm on an Ancient Disease

Antioxidants, 2018
Heat stroke (HS) is an ancient illness dating back more than 2000 years and continues to be a health threat and to cause fatality during physical exertion, especially in military personnel, fire-fighters, athletes, and outdoor laborers.
Chin Leong Lim
doaj   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang, Faist, Eugen, Jarrar, Doreid, Jochum, Marianne, Kenney, John, Schildberg, Friedrich-Wilhelm, Thiele, Volker   +6 more
core   +1 more source

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]

, 2020
The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita, Foretz, Marc, Ghosh, Pradipta, Ibeawuchi, Stella-Rita, Lim, Blaze B, Mittal, Yash, Sahoo, Debashis, Sayed, Ibrahim M, Swanson, Lee, Viollet, Benoit   +9 more
core   +3 more sources

Immunological and periodontal benefits of prebiotic polydextrose in rats with induced periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Prebiotic therapy is a promising approach for managing periodontitis due to its potential benefits in modulating the microbiome and the immune response. This study aimed to evaluate the effects of the prebiotic (PREB) polydextrose (PDX) on the development of experimental periodontitis (EP) in rats.
Raquel de S. F Nassar, Marcella C. Ribeiro, Ana Carolina P. Hernandes, Laura Z. Gianduzzo, Vanessa de P. S. Pereira, Sérgio L. S. Salvador, Edilson Ervolino, Débora S. F. Sávio, Michel R. Messora, Flávia A. C. Furlaneto   +9 more
wiley   +1 more source

Cardiac Autophagy in Sepsis

Cells, 2019
Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition.
Yuxiao Sun, Ying Cai, Qun S. Zang
doaj   +1 more source

Periodontitis during pregnancy: The effect on the gut microbiome and intestinal inflammation

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal
Richard Bright, Matthew G. Macowan, Keyuan Tian, Tracy Fitzsimmons, Rebecca L. Wilson, Claire T. Roberts, Claus T. Christophersen, Peter M. Bartold, Stephen P. Kidd, Peter S. Zilm   +9 more
wiley   +1 more source

TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis

Frontiers in Immunology
BackgroundDuring endotoxemia, immune activation rapidly increases energy needs. To meet these demands, white adipose tissue (WAT) mobilizes fatty acids through lipolysis. While fatty acids serve as energy-dense substrates, they also act as precursors for
Miguel Chirivi, Ursula Abou-Rjeileh, Madison Myers, Jair Parales-Giron, Lynn Worden, Adam L. Lock, G. Andres Contreras   +6 more
doaj   +1 more source

Pneumonia Caused by Klebsiella spp. in 46 Horses. [PDF]

, 2015
BackgroundKlebsiella spp. are implicated as a common cause of bacterial pneumonia in horses, but few reports describe clinical presentation and disease progression.Hypothesis/objectivesTo describe the signalment, clinicopathologic data, radiographic and ...
Aleman, M, Byrne, BA, Estell, KE, Kass, PH, Kozikowski, T, Reilly, CM, Swain, EA, Young, A   +7 more
core   +1 more source

Microbial burden of periodontal diseases and its clinical application: The stage, grade, and furcation matter

Journal of Periodontology, EarlyView.
Abstract Background Periodontal diseases are associated with dysbiotic oral microbial communities, but clinically applicable measures that reflect microbial burden across disease severity and progression remain limited. This study aimed to assess the oral microbial burden of periodontal diseases by evaluating salivary and subgingival lipopolysaccharide
Anbo Dong, Susanna Paju, Jaakko Leskelä, Muhammed Manzoor, Jukka Putaala, Pauli Ylikotila, Eija Könönen, Pirkko Pussinen, Svetislav Zaric   +8 more
wiley   +1 more source

Consequences of the Lack of IL-10 in Different Endotoxin Effects and its Relationship With Glucocorticoids [PDF]

, 2019
Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a ...
Barrientos, Gabriela Laura, Córdoba Moreno, Marlina Olyissa, Fontanals, Adriana Mirta, Isturiz, Martín Amadeo, Montagna, Daniela Romina, Pineda, Gonzalo Ezequiel, Ramos, Maria Victoria, Rearte, María Bárbara, Toblli, Jorge Eduardo, Todero, Maria Florencia, Yokobori, Noemí   +10 more
core   +1 more source