Results 61 to 70 of about 25,379 (184)

Synergistic Anti‐Obesity Effect of Akkermansia muciniphila AKM Lab‐01 and Garcinia cambogia Extract via Gut Microbiota Remodeling in Diet‐Induced Obese Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Combined administration of pasteurized Akkermansia muciniphila (AKM Lab‐01) and Garcinia cambogia extract (GCE) alleviates high‐fat‐diet‐induced obesity in mice by reducing adiposity, metabolic disturbances, and adipose inflammation, while remodeling gut microbiota and adipose transcriptome, revealing a gut‐host metabolic axis that underpins the ...
Baojia Huang, Zhipeng Chen, Wenbin Xue, Zilun Pu, Yalin Zhou, Sherlyn Sze Ning Koay, Ping Kong, Yingying Zhao, Lihong Tai, Zhou Lan, Yibo Xian, Amanda Juan Chen   +11 more
wiley   +1 more source

Effects of Araticum (Annona crassiflora Mart.) By‐Product on Intestinal Health Parameters in High‐Fat Diet‐Fed Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Araticum (Annona crassiflora Mart.) by‐product supplementation at 200 or 400 mg/kg for 30 days did not improve body weight, glucose tolerance, or obesity‐related metabolic markers in high‐fat diet‐fed mice. However, it increased fecal moisture and intestinal mucus, reduced fecal pH, and promoted changes in gut bacterial richness, indicating potential ...
Thamara Rosa de Souza, Fellipe Lopes de Oliveira, Sabrina Neves Casarotti, Suélem Aparecida de França Lemes, Eudes Thiago Pereira Avila, Amílcar Sabino Damazo, Lucas Amoroso Lopes de Carvalho, Daniel Guariz Pinheiro, Katia Sivieri, Maressa Caldeira Morzelle   +9 more
wiley   +1 more source

2′‐FL's Depiction of the Human Physiological Function Landscape

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The figure summarizes the multifaceted physiological effects of 2′‐fucosyllactose (2′‐FL), a major human milk oligosaccharide. The schematic illustrates the central role of the gut‐centered regulatory axis, where 2′‐FL modulates gut microbiota composition, promotes the production of short‐chain fatty acids and microbial metabolites, enhances mucus ...
Yushan Xiao, Jiahao Li, Xiaofeng Li, Yan Dai   +3 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Risk of Depressive Symptoms in Older Adults

International Journal of Geriatric Psychiatry, Volume 41, Issue 8, August 2026.
ABSTRACT Introduction There is a potential link between Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) and depression in later life. This study aims to examine whether MASLD is associated with elevated clinically relevant depressive symptoms in community‐dwelling older adults.
Marzieh Nasr Azadani, Najmeh Davoodian, Michael Berk, Daniel Clayton‐Chubb, Malcolm Forbes, Shiva Ganjali, William Kemp, Robyn L. Woods, Mojtaba Lotfaliany, John J. McNeil, Julie A. Pasco, Stuart K. Roberts, Mohammadreza Mohebbi   +12 more
wiley   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

Admission Plasma Lipopolysaccharide‐binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT This study aimed to assess whether admission plasma lipopolysaccharide‐binding protein (LBP), procalcitonin (PCT), and lactate could improve detection of nosocomial infection in cirrhotic patients presenting with upper gastrointestinal bleeding (UGIB).
Li Chen, Shan‐Shan Dun, Fang Xiao
wiley   +1 more source

Decoding Akkermansia muciniphila Effector Biology: From Microbial Molecules to Host Outcomes

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Schematic overview of the proposed gut–brain axis mechanisms linking Akkermansia muciniphila to host outcomes. A. muciniphila‐derived signals, including SCFAs and P9/GLP‐1‐related endocrine pathways, may influence epithelial barrier integrity, inflammatory responses, systemic immune signaling, and neural communication through the enteric nervous system,
Amir Arsalan Ghahari, Ainur Sadykova, Salim Davlatov, Mukaddas Xusanova, Gulrukh Indiaminova, Furkat Sobirov, Mirzamakhmud Shadmanov, Umidjon Maxamatov, Patkhiddin Nishonov, Seyed Davar Siadat   +9 more
wiley   +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon, Md. Mizanur Rahaman, Dhrubo Sarder, Md. Shadin, Shamima Akter Neela, Phurpa Wangchuk, Subir Sarker   +6 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source