Results 111 to 120 of about 55,295 (265)
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source
Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo +3 more
wiley +1 more source
Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang +3 more
wiley +1 more source
Critical roles of endogenous glucocorticoids for disease tolerance in malaria
, 2019 During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien +4 more
core +1 more source
Mechanism for development of systemic endotoxemia in patients with cirrhosis and portal endotoxemia
Kanzo, 1980 肝硬変患者の末梢エンドトキシン血症出現の機序を知る為に,肝硬変20例,非硬変7例に経皮経肝カテーテル法を用い門脈系(門脈本幹,上腸間膜静脈,脾静脈)と末梢の血液を同時に採血しエンドトキシンを測定した.門脈系血でのエンドトキシン検出率は,肝硬変,非硬変例共に上腸間膜静脈血で高く,エンドトキシン濃度は,肝硬変例の方が非硬変例に比して高い傾向にあった.門脈系血中エンドトキシン陽性の肝硬変例のうち末梢での血中エンドトキシン陽性群は,陰性群に比してICG 15分停滞率の高値,肝内短絡路の増加がみられた.即ち肝硬変患者の末梢エンドトキシン血症の出現は,有効肝血流量の減少に起因する肝の細網内皮系機能低下により門脈血液中のエンドトキシンの除去ができないためと考えられた.
Kunihiko KOHNO +5 more
openaire +2 more sources
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, EarlyView.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Neonatal limb gangrene with auto‐amputation is rare and often idiopathic. Early recognition, prompt referral, and thorough etiologic workup—despite resource limitations—are critical. Wet gangrene requires broad‐spectrum antibiotics, wound care, and timely surgical amputation to preserve growth plates and allow future prosthesis fitting.
Milki Tufa Feyisa +7 more
wiley +1 more source
Clotting and other plasma factors in experimental endotoxemia: inhibition of degradation by exogenous proteinase inhibitors. [PDF]
, 1981 Fritz, Hans +5 more
core +1 more source