Results 11 to 20 of about 54,513 (224)

Metabolic endotoxemia is dictated by the type of lipopolysaccharide

Cell Reports, 2021
Summary: Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize
Fernando F. Anhê, Nicole G. Barra, Joseph F. Cavallari, Brandyn D. Henriksbo, Jonathan D. Schertzer   +4 more
doaj   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Anthropometric indices, lipid profile, and lipopolysaccharide-binding protein levels in metabolic endotoxemia: A case-control study in Calabar Metropolis, Nigeria

Journal of Acute Disease, 2020
Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia.
Ekong Raymond Eworo, Edmund Richard Egbe, Zibril A Okhormhe, Bassey K Offor, Bassey Ikoedem Uduak, Andeshongkwe Dauda   +5 more
doaj   +1 more source

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Frontiers in Immunology, 2021
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS).
Shireen Mohammad, Christoph Thiemermann
doaj   +1 more source

Progression of the Wei-Qi-Ying-Xue syndrome, microcirculatory disturbances, in infectious diseases and treatment with traditional Chinese medicine

World Journal of Traditional Chinese Medicine, 2022
Lipopolysaccharide (LPS)-induced endotoxemia is a critical condition that initiates microcirculatory disturbance and may progress to multiple organ failure that threatens the lives of millions of people around the world each year.
Jing-Yan Han, Quan Li, Chun-Shui Pan, Kai Sun, Jing-Yu Fan   +4 more
doaj   +1 more source

Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population

BMC Immunology, 2022
Background Excessive inflammatory response is the primary cause of early death in patients with endotoxemia. Interleukin 22 (IL-22) has been shown to play critical roles in the modulation of infectious diseases, but its function in regulating immune ...
Chang Yu, Qihua Ling, Junzhe Jiao, Juhong Liu, Zhihua Huang, Fang Wang, Xuehua Sun, Xiaoni Kong   +7 more
doaj   +1 more source

Neutrophil migration during endotoxemia [PDF]

Journal of Leukocyte Biology, 1999
Abstract Endotoxemia is marked by a global activation of inflammatory responses, which can lead to shock, multiple organ failure, and the suppression of immune and wound healing processes. Neutrophils (PMNs) play a central role in some of these responses by accumulating in tissues and releasing reactive oxygen species and proteases that ...
J G, Wagner, R A, Roth
openaire   +2 more sources

Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival

Frontiers in Physiology, 2018
Sepsis syndrome is the most important cause of mortality in critically ill patients admitted to intensive care units (ICUs). However, current therapies for its prevention and treatment are still unsatisfactory, and the mortality rate is still high.
Alejandro Vallejos, Alejandro Vallejos, Pedro Olivares, Diego Varela, Diego Varela, Cesar Echeverria, Cesar Echeverria, Claudio Cabello-Verrugio, Claudio Cabello-Verrugio, Claudio Pérez-Leighton, Felipe Simon, Felipe Simon   +11 more
doaj   +1 more source

Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys

Journal of Veterinary Internal Medicine, 2020
Background Little information is available about endotoxemia in donkeys. Characterizing the systemic inflammatory response (SIRS) to lipopolysaccharide (LPS) in donkeys would provide valuable clinical and therapeutic information. The effects of meloxicam
Francisco Javier Mendoza Garcia, Carlos Gonzalez‐De Cara, Raul Aguilera‐Aguilera, Antonio Buzon‐Cuevas, Alejandro Perez‐Ecija   +4 more
doaj   +1 more source

Endotoxemia is associated with an adverse metabolic profile

Innate Immunity, 2021
Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately
Anne-Mari Määttä, Aino Salminen, Milla Pietiäinen, Jaakko Leskelä, Teemu Palviainen, Wolfgang Sattler, Juha Sinisalo, Veikko Salomaa, Jaakko Kaprio, Pirkko J Pussinen   +9 more
doaj   +1 more source