Results 11 to 20 of about 62,922 (266)

Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in Endotoxemia

Frontiers in Pharmacology, 2021
Endotoxemia is characterized by initial uncontrollable inflammation, terminal immune paralysis, significant cell apoptosis and tissue injury, which can aggravate or induce multiple diseases and become one of the complications of many diseases. Therefore,
Zixuan Liu, Zixuan Liu, Wenxiang Wang, Wenxiang Wang, Jie Luo, Jie Luo, Yingrui Zhang, Yingrui Zhang, Yunsen Zhang, Zhiqiang Gan, Zhiqiang Gan, Xiaofei Shen, Yi Zhang, Yi Zhang, Xianli Meng   +14 more
doaj   +1 more source

Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Translocation of lipopolysaccharide from gram‐negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and ...
Jaakko Leskelä, Iiro Toppila, Mari‐Anne Härma, Teemu Palviainen, Aino Salminen, Niina Sandholm, Milla Pietiäinen, Elisa Kopra, Jean‐Paul Pais de Barros, Mariann I. Lassenius, Anmol Kumar, Valma Harjutsalo, Kajsa Roslund, Carol Forsblom, Anu Loukola, Aki S. Havulinna, Laurent Lagrost, Veikko Salomaa, Per‐Henrik Groop, Markus Perola, Jaakko Kaprio, Markku Lehto, Pirkko J. Pussinen   +22 more
doaj   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Metabolic endotoxemia is dictated by the type of lipopolysaccharide

Cell Reports, 2021
Summary: Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize
Fernando F. Anhê, Nicole G. Barra, Joseph F. Cavallari, Brandyn D. Henriksbo, Jonathan D. Schertzer   +4 more
doaj   +1 more source

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Frontiers in Immunology, 2021
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS).
Shireen Mohammad, Christoph Thiemermann
doaj   +1 more source

Progression of the Wei-Qi-Ying-Xue syndrome, microcirculatory disturbances, in infectious diseases and treatment with traditional Chinese medicine

World Journal of Traditional Chinese Medicine, 2022
Lipopolysaccharide (LPS)-induced endotoxemia is a critical condition that initiates microcirculatory disturbance and may progress to multiple organ failure that threatens the lives of millions of people around the world each year.
Jing-Yan Han, Quan Li, Chun-Shui Pan, Kai Sun, Jing-Yu Fan   +4 more
doaj   +1 more source

Interleukin-22 protects from endotoxemia by inducing suppressive F4/80+Ly6GhiLy6Chi cells population

BMC Immunology, 2022
Background Excessive inflammatory response is the primary cause of early death in patients with endotoxemia. Interleukin 22 (IL-22) has been shown to play critical roles in the modulation of infectious diseases, but its function in regulating immune ...
Chang Yu, Qihua Ling, Junzhe Jiao, Juhong Liu, Zhihua Huang, Fang Wang, Xuehua Sun, Xiaoni Kong   +7 more
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Neutrophil migration during endotoxemia [PDF]

Journal of Leukocyte Biology, 1999
Abstract Endotoxemia is marked by a global activation of inflammatory responses, which can lead to shock, multiple organ failure, and the suppression of immune and wound healing processes. Neutrophils (PMNs) play a central role in some of these responses by accumulating in tissues and releasing reactive oxygen species and proteases that ...
J G, Wagner, R A, Roth
openaire   +2 more sources

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival

Frontiers in Physiology, 2018
Sepsis syndrome is the most important cause of mortality in critically ill patients admitted to intensive care units (ICUs). However, current therapies for its prevention and treatment are still unsatisfactory, and the mortality rate is still high.
Alejandro Vallejos, Alejandro Vallejos, Pedro Olivares, Diego Varela, Diego Varela, Cesar Echeverria, Cesar Echeverria, Claudio Cabello-Verrugio, Claudio Cabello-Verrugio, Claudio Pérez-Leighton, Felipe Simon, Felipe Simon   +11 more
doaj   +1 more source