For release of parenteral drug products, bacterial endotoxin testing is one of a panel of necessary tests. In order to ensure the validity of such tests, various controls are performed, including demonstration of compendial method suitability or method ...
René Bech Ørving +5 more
doaj +1 more source
Is there NO treatment for severe sepsis? [PDF]
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core +2 more sources
Systemic inflammatory response to inhaled endotoxin does not correlate with airway response
Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood.
Amika K. Sood +6 more
doaj +1 more source
Seasonal Changes in Endotoxin Exposure and Its Relationship to Exhaled Nitric Oxide and Exhaled Breath Condensate pH Levels in Atopic and Healthy Children. [PDF]
Endotoxin, a component of the cell walls of gram-negative bacteria, is a contaminant in organic dusts (house dust) and aerosols. In humans, small amounts of endotoxin may cause a local inflammatory response.
Gwo-Hwa Wan +4 more
doaj +1 more source
Biochemistry Of Endotoxins [PDF]
B IOCHEMISTRY OF LIPID A AND CORE DOMAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 Isolation, Structure, and Conformation of Lipid A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 Lipid A Structures in Non-enteric Bacteria . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire +2 more sources
Flow and filtration imaging of single use sterile membrane filters
Sterile filters incorporating endotoxin adsorption function emerged recently to pretreat dialysate liquids fed to a hemodialysis filtration process. Their application significantly enhances the survival rate during dialysis treatment as they function as ...
Krause, Bernd +3 more
core +1 more source
Consequences of the Lack of IL-10 in Different Endotoxin Effects and its Relationship With Glucocorticoids [PDF]
Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a ...
Barrientos, Gabriela Laura +10 more
core +1 more source
Endotoxin Tolerance Induced by Detoxified Endotoxin (Endotoxoid)
SummaryNonspecific tolerance towards the lethal action of endotoxins from different gram-negative bacteria can be induced within 24 hours by a single injection of S. marcescens endotoxoid. This endotoxin tolerance is not based on circulating antibodies.
B, Urbaschek, A, Nowotny
openaire +2 more sources
Effect of Escherichia coli endotoxin on Archachatina marginata haemolymph coagulation system [PDF]
The effect of _E. coli_ endotoxin on the heamolymph coagulation response of _Archachatina marginata_ was studied. Heamocyte Lysate(HL), Haemocyte Lysate Supernatant(HLS) and Haemocyte Lysate Debris (HLD) were exposed to _Escherichia coli_ endotoxin ...
Adenike Oladiji +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

