Results 81 to 90 of about 41,675 (262)
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
Snake antivenoms: adverse reactions and production technology
Journal of Venomous Animals and Toxins including Tropical Diseases, 2009 Antivenoms have been widely used for more than a century for treating snakebites and other accidents with poisonous animals. Despite their efficacy, the use of heterologous antivenoms involves the possibility of adverse reactions due to activation of the
VM Morais, H Massaldi
doaj +1 more source
Endotoxins of enteric pathogens are chemotactic factors for human neutrophils
, 2002 Early activation of human peripheral blood polymorphonuclear neutrophils is characterized by their morphological changes from spherical to polarized shapes. The endotoxins from enteric pathogens (S. dysenteriae type 1, V.
Laila N. Islam +4 more
core +1 more source
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Serum lipolysaccharide concentrations of dairy cows in pre- and postpartum period and with subclinical laminitis [PDF]
Journal of Central European AgricultureThe aim of this study was to compare the LPS blood concentrations and metabolic status in the peripartum period and in the late lactation phase in dairy cows.
Pavel Gomulec, Pavol Mudroň
doaj +1 more source
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo +6 more
wiley +1 more source
Detection of Endotoxins and Bacterial Agents in Collected Blood Bags and their Recipients
Journal of High Institute of Public Health, 2009 Bacterial contamination of blood and its cellular components remains an unresolved problem in transfusion medicine, and is considered to be the most common microbiological cause of transfusion associated morbidity and mortality.
Mohamed ON +3 more
doaj +1 more source
Annals of Agricultural and Environmental Medicine, 2015 For assessment of the dose-response relationship between concentrations of microbial agents in the air of various agricultural settings and occurrence of work-related symptoms in exposed workers, a meta-analysis of the results obtained in 1994–2007 on ...
Barbara Mackiewicz +2 more
doaj +1 more source
, 2007 To determine whether non-enterobacterial endotoxins, which are likely to constitute the majority of the circulating endotoxin pool, may stimulate coronary artery endothelial cell activation.
Webb, D.J., Spickett, C.M., Erridge, C.
core +1 more source