Results 111 to 120 of about 2,705,124 (338)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

BMC Biotechnology, 2010
Background RNA extracted from formalin-fixed paraffin-embedded (FFPE) samples is chemically modified and degraded, which compromises its use in gene expression studies.
Dobrovic Alexander, Mikeska Thomas, Takano Elena A, Byrne David J, Fox Stephen B   +4 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Determination of Trace Amounts of Hydrofluoric Acid in Non-Aqueous Solutions by the Coulometric Titration Method

Sensors, 2018
For monitoring of trace amounts of hydrofluoric acid in the organic fluorine chemical industry, a facile method for determination of the hydrofluoric acid in an ethanol solution of lithium chloride, by coulometric titration, was proposed.
Cairui Huang, Congcong Shen, Ling Jin, Hongwei Cai   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Discriminating Electroweak-ino Parameter Ordering at the LHC and Its Impact on LFV Studies

, 2009
Current limit on the dark matter relic abundance may suggest that $|\mu|$ should be smaller than prediction in the minimal supergravity scenario (mSUGRA) for moderate $m_0$ and $m_{1/2}$. The electroweak-ino parameter $M_1, M_2$ and $|\mu|$ are then much
A. Barr, ATLAS collaboration, B.C. Allanach, B.K. Gjelsten, D. Clowe ., E. Richter-Was, F.E. Paige, G. Corcella ., H. Baer, H. Baer, H. Baer, Junji Hisano, M. Bona ., Mihoko M Nojiri, N. Arkani-Hamed, SDSS collaboration, SuperKEKB Physics Working Group collaboration, Supernova Cosmology Project collaboration, Supernova Cosmology Project collaboration, Supernova Search Team collaboration, Supernova Search Team collaboration, Supernova Search Team collaboration, W.S. Cho, Warintorn Sreethawong, WMAP collaboration, WMAP collaboration, WMAP collaboration   +26 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The status of |Vub|

, 2004
I survey the theoretical and experimental information available for determination of |Vub| with inclusive and exclusive techniques. Using recent experimental and theoretical advances, I outline a procedure in which the inclusive information can be ...
Gibbons, Lawrence
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An AIE-active probe acts as novel tool for rapid and accurate quantitative antifungal susceptibility assessment

Frontiers in Microbiology
ObjectivesCommon antifungal susceptibility testing methods are often time-consuming and subject to interpretation bias in endpoint determination, making them inadequate for clinical applications. We aim to develop a rapid and accurate quantitative method
Fen Zheng, Fen Zheng, Xiaoxue Ge, Yajuan Guan, Qixian Zhou, Renren Shi, Jiayi Zhao, Bo Situ, Jing Zhang, Yongyu Rui   +9 more
doaj   +1 more source