Results 111 to 120 of about 176,455 (318)

Determination of bacterial endotoxins in parenteral solutions produced on a small scale in a clinical hospital [PDF]

Makedonsko Farmacevtski Bilten
Two different limulus amoebocyte lysate assays of bacterial endotoxins in parenteral solutions produced on a small scale in a clinical hospital are evaluated.
Renata Bozhinovska Popovska, Tatjana Gjurichikj, Branislava Janeva, Jelena Acevska, Aneta Dimitrovska   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The role of immunohistochemical analysis in determining the molecular subtypes of bladder cancer

Успехи молекулярной онкологии
Introduction. The results of genomic profiling of muscle-invasive bladder cancer (BC) based on messenger RNA (mRNA) extraction showed significant molecular variety of the tumors underlying the wide spectrum of clinical manifestations and responses to ...
M. V. Berkut, A. S. Artemyeva, A. V. Khokhlova, A. I. Saad, A. K. Nosov   +4 more
doaj   +1 more source

Mass Measurement of the Decaying Bino at the LHC

, 2008
In some class of supersymmetric (SUSY) models, the neutral Wino becomes the lightest superparticle and the Bino decays into the Wino and standard-model particles.
Aad, Alwall, Asai, Asai, Bachacou, Feng, Gherghetta, Giudice, Ibe, Maltoni, Moroi, Osamu Jinnouchi, Randall, Satoshi Shirai, Shoji Asai, Sjostrand, Stelzer, T.T. Yanagida, Takeo Moroi, Toharia, Wells, Yuya Azuma   +21 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Chest Radiographs for Pediatric TB Diagnosis: Interrater Agreement and Utility

Interdisciplinary Perspectives on Infectious Diseases, 2014
The chest radiograph (CXR) is considered a key diagnostic tool for pediatric tuberculosis (TB) in clinical management and endpoint determination in TB vaccine trials. We set out to compare interrater agreement for TB diagnosis in western Kenya.
G. Kaguthi, V. Nduba, J. Nyokabi, F. Onchiri, R. Gie, M. Borgdorff   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Considerations for Endpoint Titer Determination in Syphilis Testing Using Newly Marketed, Automated Rapid Plasma Reagin Instruments [PDF]

, 2023
Mayur Shukla, Lara Pereira, Yongcheng Sun, Yetunde Fakile, Ellen N. Kersh, Weiping Cao   +5 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source