Results 61 to 70 of about 73,823 (281)

Wheeze is an unreliable endpoint for bronchial methacholine challenges in preschool children [PDF]

, 2022
BACKGROUND: Onset of wheeze is the endpoint often used in the determination of a positive bronchial challenge test (BCT) in young children who cannot perform spirometry.
Miyazawa, Naomi, Christopher Mjaanes, Mjaanes, Christopher, Gleason, Melanie, Spahn, Joseph D, Ronina Covar, Melanie Gleason, Stewart, Lora, Lora Stewart, Reed Shimamoto, Joseph D. Spahn, Peroni, Diego, Diego Peroni, Pasquale Comberiati, Spahn, Joseph D., Shimamoto, Reed, Covar, Ronina, Comberiati, Pasquale, Naomi Miyazawa   +18 more
core   +1 more source

DETERMINATION OF ALKALINITY AND DISSOCIATION CONSTANTS OF HIGH SALINITY WATERS: USE OF F5BC TITRATION FUNCTION

Eclética Química, 2018
Measurements of parameters expressed in terms of carbonic species such as Alkalinity and Acidity of saline waters do not analyze the influence of external parameters to the titration such as Total free and associated Carbonic Species Concentration ...
Bernadete F. Cavalcanti, Lourdes Cristina Lucena Agostinho, Luciano Nascimento   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cardiac magnetic resonance imaging versus computed tomography to guide transcatheter aortic valve replacement: study protocol for a randomized trial (TAVR-CMR)

Trials, 2022
Background The standard procedure for the planning of transcatheter aortic valve replacement (TAVR) is the combination of echocardiography, coronary angiography, and cardiovascular computed tomography (TAVR-CT) for the exact determination of the aortic ...
Gert Klug, Sebastian Reinstadler, Felix Troger, Magdalena Holzknecht, Martin Reindl, Christina Tiller, Ivan Lechner, Priscilla Fink, Mathias Pamminger, Christian Kremser, Hanno Ulmer, Axel Bauer, Bernhard Metzler, Agnes Mayr   +13 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Evaluation of cleanup endpoint parameters for sandy beaches polluted with heavy fuel oil [PDF]

, 2017
This research work aims at evaluating the accuracy of a clean-up endpoint set by Lebanese authorities for sandy beaches following an oil spill that hit Lebanon in 2006.
F. Al Ali, G. Mansour, Al Ali, F., Sabra, Nada Y., Sukhn, Carol M.S., Hatjian, Berj A., N. Sabra, Mansour, Georges, B. Hatjian, C. Sukhn   +9 more
core   +1 more source

Challenges in translating end points from trials to observational cohort studies in oncology

Clinical Epidemiology, 2016
Anne Gulbech Ording,1 Deirdre Cronin-Fenton,1 Vera Ehrenstein,1 Timothy L Lash,1,2 John Acquavella,1 Mikael Rørth,1 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of&
Ording AG, Cronin-Fenton D, Ehrenstein V, Lash TL, Acquavella J, Rørth M, Sørensen HT   +6 more
doaj  

An alternative trial-level measure for evaluating failure-time surrogate endpoints based on prediction error

Contemporary Clinical Trials Communications, 2019
To validate a failure-time surrogate for an established failure-time clinical endpoint such as overall survival, the meta-analytic approach is commonly used.
Shaima Belhechmi, Stefan Michiels, Xavier Paoletti, Federico Rotolo   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Initial visual information determines endpoint precision for rapid pointing

Vision Research, 2006
We investigated how visual noise in the initial estimate of target location affects precision for rapid pointing. Visual localization thresholds (an error measure) rise systematically with eccentricity, doubling at eccentricities of a degree or less. Previous work, which we confirmed, has shown that the precision of pointing, measured by the standard ...
Ma-Wyatt, A., McKee, S.
openaire   +3 more sources