Results 81 to 90 of about 313,385 (288)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
International Journal of Disabilities Sports and Health SciencesAerobic endurance is an important component in futsal sports games, so it requires an exercise that can increase aerobic endurance. This study aims to evaluate the effectiveness of circuit training with fartlek exercises to increase aerobic endurance ...
M Haris Satria +5 more
doaj +1 more source
BMC Genomics, 2020 Background Protein supplementation improves physiological adaptations to endurance training, but the impact on adaptive changes in the skeletal muscle transcriptome remains elusive.
Pim Knuiman +4 more
doaj +1 more source
Analysis of the Effects of Dietary Pattern on the Oral Microbiome of Elite Endurance Athletes [PDF]
, 2019 Although the oral microbiota is known to play a crucial role in human health, there are few studies of diet x oral microbiota interactions, and none in elite athletes who may manipulate their intakes of macronutrients to achieve different metabolic ...
Burke, Louise M +8 more
core +3 more sources
Endurance Training Of Trained Athletes-An Electromyogram Study
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005 Little is known about the mechanism that improves the capabilities of athletes by high, intensity interval training (HIT). This study was conducted to determine the neurophysiological changes due to HIT. Changes in surface electromyography (SEMG) in well-trained endurance cyclists due to the training were identified.
J, Jemma +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Protein and the Adaptive Response With Endurance Training: Wishful Thinking or a Competitive Edge?
Frontiers in Physiology, 2018 The significance of carbohydrates for endurance training has been well established, whereas the role of protein and the adaptive response with endurance training is unclear. Therefore, the aim of this perspective is to discuss the current evidence on the
Pim Knuiman +4 more
doaj +1 more source
Impact of exercise endurance training on pur gene expression and cardiac function [PDF]
, 2016 Introduction: Endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (MHC) proteins. On the other side, Purine-rich element-binding protein β (pur) decreases the αMHC gene expression.
Anjomshoa, Maryam. +3 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Physiological ReportsThis meta‐analysis examined whether HIIT outperforms low‐intensity endurance training (LIET), generic training (GT), or sport‐specific drills (SSD) in improving aerobic and anaerobic endurance in youth athletes.
Manuel Matzka +3 more
doaj +1 more source