Results 71 to 80 of about 316,766 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Optimizing Arm Muscle Endurance in Pencak Silat Athletes: Insights from a Literature Review

Tanjungpura Journal of Coaching Research
Background and Study Aim. Pencak Silat is a martial art that demands exceptional physical strength, agility, and endurance. Among these, arm muscle endurance plays an important role in performing effective offensive and defensive maneuvers. Improving arm
Jefrio Demitrimus Nubatonis, Sulistiyono Sulistiyono, Muhamad Husein, Irvan Septianto, Salmon Runesi, Dwi Manna Nazmi Zakiah, Julian Dewantara, Jihan Azrina, Syahrizal Islam, Vince Louisse D. Salacup   +9 more
doaj   +1 more source

Effects of Endurance Exercise Training on The Motor and Non-Motor Features of Parkinson's Disease: A Review

Journal of Parkinson’s Disease, 2015
Background: Despite the benefits of medications and surgical interventions for Parkinson's disease (PD), these treatments are not without complications and neuroprotective strategies are still lacking. Therefore, there is a need for effective alternative
Guillaume Lamotte, Miriam R. Rafferty, Janey Prodoehl, Wendy M. Kohrt, Cynthia L. Comella, Tanya Simuni, Daniel M. Corcos   +6 more
doaj   +1 more source

The Effects and Differences of Sprint Interval Training, Endurance Training and the Training Types Combined on Physiological Parameters and Exercise Performance [PDF]

, 2014
Sprint Interval Training (SIT) is a time efficient way in order to elicit similar changes as Endurance Training (ET) on aerobic capacity, with the purpose of the exercise training to alter physiological systems and exceed resting homeostasis to improve ...
Hurst, Rachel Ann
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Signalling Responses Following Varying Sequencing of Strength and Endurance Training in a Fed State. [PDF]

, 2015
The objective of this study was to compare anabolic signalling responses to differing sequences of concurrent strength and endurance training in a fed state.Eighteen resistance-trained males were randomly assigned to the following experimental conditions;
French, DN, Hamilton, DL, Howatson, G, Jones, TW, Price, OJ, Russell, M, St Clair Gibson, A, Walshe, IH   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficacy of an 8-Week Concurrent Strength and Endurance Training Programme on Hand Cycling Performance [PDF]

, 2018
The aim of the present study was to investigate the effects of an 8-week concurrent strength and endurance training programme in comparison to endurance training only on several key determinants of hand cycling performance. Five H4 and five H3 classified
Blagrove, R., Hunt, A., Nevin, J., Patterson, S., Price, M., Smith, Paul M., Waldron, M.   +6 more
core   +2 more sources

Endurance and Training.

Journal of exercise physiology, 1994
全身持久力とトレーニングについて，運動負荷試験，全身持久力の指標，トレーニングの実際について概説する。全身持久力を評価するために用いられる運動負荷試験について，その運動負荷装置の種類と特徴，プロトコール等について述べる。全身持久力の指標として，最大酸素摂取量，無酸素性作業閾値，PWC170等がある。それらの指標の測定方法等について述べる。トレーニングについては原則，方法，影響について述べ，著者が行った全身持久力トレーニングの効果判定の諸問題について述べる。
openaire   +2 more sources