Results 71 to 80 of about 104,109 (310)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Inspiratory muscle training abolishes the blood lactate increase associated with volitional hyperpnoea superimposed on exercise and accelerates lactate and oxygen uptake kinetics at the onset of exercise

, 2011
We examined the effects of inspiratory muscle training (IMT) upon volitional hyperpnoea-mediated increases in blood lactate ([lac−]B) during cycling at maximal lactate steady state (MLSS) power, and blood lactate and oxygen uptake kinetics at the onset ...
Brown, PI, Johnson, Michael A., Graham R. Sharpe, Johnson, MA, Brown, Peter I., Michael A. Johnson, Peter I. Brown, Sharpe, GR, Sharpe, Graham R.   +8 more
core   +1 more source

Protein and the Adaptive Response With Endurance Training: Wishful Thinking or a Competitive Edge?

Frontiers in Physiology, 2018
The significance of carbohydrates for endurance training has been well established, whereas the role of protein and the adaptive response with endurance training is unclear. Therefore, the aim of this perspective is to discuss the current evidence on the
Pim Knuiman, Maria T. E. Hopman, Maria T. E. Hopman, Conor Verbruggen, Marco Mensink   +4 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The effect of speed endurance training on increasing aerobic endurance of futsal extracurricular students

Purpose: This study aims to analyze the effect of speed-endurance training on increasing aerobic capacity (VO₂max) among students participating in extracurricular futsal activities.
Bird, Stephen P., Febriliana, Fanesa Amanda, Kusnanik, Nining Widyah   +2 more
core   +1 more source

Right heart exercise-training-adaptation and remodelling in endurance athletes

, 2021
Long-term sports training leads to myocardial adaptations, with remodelling of the heart chambers. However, while myocardial adaptations of the left heart are well described, remodelling of the right heart and its impact on the development of arrhythmias
Marco Pilone, Francisco Javer Calderon Montero, Conti, Valeria, Maffulli, Nicola, Valeria Conti, Migliorini, Filippo, Juan José Ramos-Álvarez, Ramos Álvarez, Juan José, Calderón Montero, Francisco Javier, Barriopedro, María, Nicola Maffulli, Filippo Migliorini, María I. Barriopedro, Pilone, Marco   +13 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Contemporary Periodization of Altitude Training for Elite Endurance Athletes: A Narrative Review

, 2019
Since the 1960s there has been an escalation in the purposeful utilization of altitude to enhance endurance athletic performance. This has been mirrored by a parallel intensification in research pursuits to elucidate hypoxia-induced adaptive mechanisms ...
Stellingwerff, Trent, Sharma, Avish P, Mujika, Inigo   +2 more
core   +1 more source

EFFECTIVENESS OF LAND BASED ENDURANCE TRAINING VERSUS AQUATIC BASED ENDURANCE TRAINING ON IMPROVING ENDURANCE IN NORMAL INDIVIDUALS

International Journal of Physiotherapy, 2015
Background: Recently the exercises and fitness professionals have adopted water as an alternative medium for delivering programs to improve fitness and health.
Vinod Kumar .K .C , Sabitha Eunice Regima, Vikranth .G .R   +2 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source