Results 51 to 60 of about 36,376 (264)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Physics of beam-driven ion cyclotron emission in the large plasma device

Nuclear Fusion
Ion cyclotron emission (ICE) is widely observed from spatially localised minority energetic ion populations in toroidal magnetically confined fusion (MCF) plasmas, both tokamaks and stellarators.
O. Samant, R.O. Dendy, S.C. Chapman, S.K.P. Tripathi, T. Carter, B. Van Compernolle, J.W.S. Cook   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Orbit-space sensitivity of two-step reaction gamma-ray spectroscopy

Nuclear Fusion
We calculate the orbit-space sensitivity of two-step reaction gamma-ray spectroscopy diagnostics in toroidally symmetric magnetic equilibria, using the reaction between alpha particles and beryllium-9 as an example.
A. Valentini, H. Järleblad, M. Nocente, J. Eriksson, S. Fugazza, O. Hyvärinen, V. Kiptily, D. Moseev, B.C.G. Reman, M. Rud, A. Snicker, L. Stagner, M. Salewski, JET Contributors   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Observation of modes in the sub-cyclotronic range of frequencies in JET

Nuclear Fusion
The excitation of modes in the JET tokamak in the sub-cyclotronic range of frequencies (frequencies comprised between the Alfvén frequency and the cyclotron frequency) is for the first time reported.
F. Nabais, D. Borba, R. Coelho, J. Ferreira, A. Figueiredo, P. Rodrigues, S.E. Sharapov, JET Contributors   +7 more
doaj   +1 more source

Low-frequency turbulence suppression by amplification of synchronized zonal flow with energetic particle driven modes

Nuclear Fusion, 2023
We investigate the suppression of the turbulent transport associated to the emergence of spontaneous internal transport barriers, due to the combined collective effects played by trapped electrons and energetic passing ions.
A. Ghizzo, D. Del Sarto
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source