Results 71 to 80 of about 882,651 (290)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Orbit-space sensitivity of two-step reaction gamma-ray spectroscopy

Nuclear Fusion
We calculate the orbit-space sensitivity of two-step reaction gamma-ray spectroscopy diagnostics in toroidally symmetric magnetic equilibria, using the reaction between alpha particles and beryllium-9 as an example.
A. Valentini, H. Järleblad, M. Nocente, J. Eriksson, S. Fugazza, O. Hyvärinen, V. Kiptily, D. Moseev, B.C.G. Reman, M. Rud, A. Snicker, L. Stagner, M. Salewski, JET Contributors   +13 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Loss of Energetic Ions Comprising the Ring Current Populations of Jupiter's Middle and Inner Magnetosphere

, 2022
International audienceThe low-altitude, polar orbit of the Juno mission allows the Jupiter Energetic Particle Detector Instrument to view into, and resolve, the loss cone of energetic ions comprising the low-altitude extension of Jupiter's ring current ...
Q. Nénon, Nénon, Q., F. Bagenal, Allegrini, F., V. Hue, Clark, G., Gershman, D. J., J. E. P. Connerney, W. S. Kurth, F. Allegrini, M. Imai, Smith, H. T., Paranicas, C. P., B. H. Mauk, G. Clark, C. P. Paranicas, A. H. Sulaiman, H. T. Smith, Connerney, J. E. P., A. M. Rymer, Kollmann, P., Haggerty, D. K., D. J. Gershman, D. K. Haggerty, Rymer, A. M., P. Kollmann, Hue, V., Sulaiman, A. H., Bolton, S. J., S. J. Bolton, Mauk, B. H., Kurth, W. S., Bagenal, F., Imai, M.   +33 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Enhanced acceleration of energetic ions by oblique shock waves [PDF]

, 2000
Interactions of energetic ions with a shock wave propagating obliquely to a magnetic field are studied by means of a one-dimensional, relativistic, electromagnetic, particle simulation code with full ion and electron dynamics.
Yukiharu Ohsawa, Tomohiro Masaki, Masaki, Tomohiro, Hasegawa, Hiroki, Hiroki Hasegawa, Ohsawa, Yukiharu, 13813, 13814, 13812   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Double-kink Fishbone Instability Caused by Circulating Energetic Ions [PDF]

, 2004
The destabilization of double kink modes by the circulating energetic ions in tokamaks with the plasma current having an off-axis maximum is studied. It is shown that the high-frequency fishbone instability [Energetic Particle Mode (EPM)] and the low ...
Kolesnichenko, Ya. I., White, R. B., V. S. Marchenko, Lutsenko, V. V., Ya. I. Kolesnichenko, R. B. White, V. V. Lutsenko, Marchenko, V. S.   +7 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source