Results 81 to 90 of about 882,651 (290)

Observation of Enhanced Radial Transport of Energetic Ion due to Energetic Particle Mode Destabilized by Helically-trapped Energetic Ion in the Large Helical Device [PDF]

0000-0003-4555-1837A deuterium experiment was initiated to achieve higher-temperature and higher-density plasmas in March 2017 in the Large Helical Device (LHD).
LHD Experiment Group,, The LHD Experiment Group,, Kawase, Hiroki, SEKI, Ryosuke, OSAKABE, Masaki, OGAWA, Kunihoro, ISOBE, Mitsutaka, Nishitani, T.   +7 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Observation of modes in the sub-cyclotronic range of frequencies in JET

Nuclear Fusion
The excitation of modes in the JET tokamak in the sub-cyclotronic range of frequencies (frequencies comprised between the Alfvén frequency and the cyclotron frequency) is for the first time reported.
F. Nabais, D. Borba, R. Coelho, J. Ferreira, A. Figueiredo, P. Rodrigues, S.E. Sharapov, JET Contributors   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Energetic ion beams and sputtering [PDF]

Nature, 1976
Ion Implantation, Sputtering and Their Applications. By P. D. Townsend, J. C. Kelly and N. E. W. Hartley. Pp. ix+333. (Academic: London and New York, June 1976.) £13; $32.25.
openaire   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Energetic Particles from Quasi-separatrix Layers and Current Sheets at the Sun

The Astrophysical Journal
Quasi-separatrix layers (QSLs) at the Sun are created in regions where channels of open magnetic flux have footpoints near regions of large-scale closed magnetic flux. These regions show rapid changes in curvature and field strength.
Nathan A. Schwadron, Ronald M. Caplan, Jon A. Linker, Erika Palmerio, Matthew A. Young   +4 more
doaj   +1 more source

Accurate Measurement of Defect Generation Rates in Silicon Carbide Irradiated with Energetic Ions. [PDF]

ACS Omega, 2023
Guo L, Peng S, Liu Y, Tian S, Zhou W, Wang H, Xue J.   +6 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source