Results 81 to 90 of about 41,384 (308)

Understanding turbulence suppression in JET D–T plasma with highly energetic fast ions via global gyrokinetic GENE simulations

Nuclear Fusion
This study focuses on understanding how turbulence is suppressed in particularly heated JET plasma discharges showing enhanced confinement, namely $99896$ , which uses a nearly 50–50 deuterium–tritium mixture, showing signs of enhanced plasma confinement.
A. Di Siena, J. Garcia, G. Merlo, A. Bañón Navarro, F. Sheffield, E. Poli, A. Ishizawa, Ye.O. Kazakov, J. Varela, T. Görler, F. Jenko, JET Contributors, the EUROfusion Tokamak Exploitation Team   +12 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ATEP: an advanced transport model for energetic particles

Nuclear Fusion
In this paper we report on the implementation and verification of a phase-space resolved energetic particle (EP) transport model. It is based on a first-principle theoretical framework, i.e.
Ph. Lauber, M. Falessi, G. Meng, T. Hayward-Schneider, V.-A. Popa, F. Zonca, M. Schneider   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Particle injection and the structure of energetic-particle-modified shocks

The Astrophysical Journal, 1992
A macroscopic 'self-consistent' nonlinear two-fluid model is developed for energetic-particle-modeled shocks. The model incorporates particle exchange between a thermal gas and an energetic population via a 'thermal leakage' mechanism. In the model, injection is regarded as a process whereby particles in the cooler thermal core of a total particle ...
G. P. Zank, G. M. Webb, D. J. Donohue
openaire   +1 more source

Assessing the impact of alpha particles on thermal confinement in JET D-T plasmas through global GENE-Tango simulations

Nuclear Fusion
The capability of the global, electromagnetic gyrokinetic GENE code interfaced with the transport Tango solver is exploited to address the impact of fusion alpha particles (in their dual role of fast particles and heating source) on plasma profiles and ...
A. Di Siena, J. Garcia, R. Bilato, K. Kirov, J. Varela, A. Bañón Navarro, Hyun-Tae Kim, C. Challis, J. Hobirk, A. Kappatou, E. Lerche, D. Spong, C. Angioni, T. Görler, E. Poli, M. Bergmann, F. Jenko, JET contributors   +17 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Very narrow coronal mass ejections producing solar energetic particles [PDF]

, 2018
Aims. Our main aim is to study the relationship between low-energy solar particles (energies below 1 MeV) and very narrow coronal mass ejections (jets with angular width 20). Methods.
Michałek, Grzegorz, Wheatland, M. S., N. Gopalswamy, G. Michalek, Gopalswamy, N., Michalek, G., M. S. Wheatland, K. Bronarska, Bronarska, Katarzyna, Bronarska, K., Wheatland, Michael S.   +10 more
core   +1 more source

Solar Energetic Particles

, 2021
Solar energetic particles (SEPs) have been studied for over seven decades, initially from ground-based instrumentation and now routinely from spacecraft throughout the heliosphere.
Linghua Wang, Wang, Linghua, Cohen, Christina M. S., Li, Gang, Gang Li, Shih, Albert Y., Mason, Glenn M., Christina M. S. Cohen, Albert Y. Shih, Glenn M. Mason   +9 more
core   +1 more source