Results 61 to 70 of about 29,434 (262)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Acceleration and Propagation of Solar Energetic Particles [PDF]

Space Science Reviews, 2017
Solar Energetic Particles (SEPs) are an important component of Space Weather, including radiation hazard to humans and electronic equipment, and the ionisation of the Earth's atmosphere. We review the key observations of SEPs, our current understanding of their acceleration and transport, and discuss how this knowledge is incorporated within Space ...
Klein, Karl-Ludwig, Dalla, Silvia
openaire   +3 more sources

Understanding turbulence suppression in JET D–T plasma with highly energetic fast ions via global gyrokinetic GENE simulations

Nuclear Fusion
This study focuses on understanding how turbulence is suppressed in particularly heated JET plasma discharges showing enhanced confinement, namely $99896$ , which uses a nearly 50–50 deuterium–tritium mixture, showing signs of enhanced plasma confinement.
A. Di Siena, J. Garcia, G. Merlo, A. Bañón Navarro, F. Sheffield, E. Poli, A. Ishizawa, Ye.O. Kazakov, J. Varela, T. Görler, F. Jenko, JET Contributors, the EUROfusion Tokamak Exploitation Team   +12 more
doaj   +1 more source

Design of an interplanetary ultralow-noise three-dimensional energetic particle spectrometer

地球与行星物理论评
The origin and acceleration of solar and heliospheric energetic particles have been prevalent research frontiers in space physics. Solar and heliospheric energetic particles measured in the interplanetary medium (IPM) can be classified into two major ...
Xiangqian Yu, Linghua Wang, Yongfu Wang, Weihong Shi, Qiugang Zong, Xin Yang, Youlong Wang, Yuguang Ye, Hongfei Chen, Hong Zou   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ATEP: an advanced transport model for energetic particles

Nuclear Fusion
In this paper we report on the implementation and verification of a phase-space resolved energetic particle (EP) transport model. It is based on a first-principle theoretical framework, i.e.
Ph. Lauber, M. Falessi, G. Meng, T. Hayward-Schneider, V.-A. Popa, F. Zonca, M. Schneider   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Energetic Particles from Quasi-separatrix Layers and Current Sheets at the Sun

The Astrophysical Journal
Quasi-separatrix layers (QSLs) at the Sun are created in regions where channels of open magnetic flux have footpoints near regions of large-scale closed magnetic flux. These regions show rapid changes in curvature and field strength.
Nathan A. Schwadron, Ronald M. Caplan, Jon A. Linker, Erika Palmerio, Matthew A. Young   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Assessing the impact of alpha particles on thermal confinement in JET D-T plasmas through global GENE-Tango simulations

Nuclear Fusion
The capability of the global, electromagnetic gyrokinetic GENE code interfaced with the transport Tango solver is exploited to address the impact of fusion alpha particles (in their dual role of fast particles and heating source) on plasma profiles and ...
A. Di Siena, J. Garcia, R. Bilato, K. Kirov, J. Varela, A. Bañón Navarro, Hyun-Tae Kim, C. Challis, J. Hobirk, A. Kappatou, E. Lerche, D. Spong, C. Angioni, T. Görler, E. Poli, M. Bergmann, F. Jenko, JET contributors   +17 more
doaj   +1 more source