Results 31 to 40 of about 57,704 (234)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Three-dimensional characterization of modifications in sapphire exposed to laser-induced damage using multimodal spectral microimaging

Scientific Reports
Sapphire (Al2O3) is a commonly used dielectric material with many applications in lasers and optical systems. Owing to its high resistivity to laser induced damage, it is particularly suitable for use in high power laser systems.
Raymond P. McBride, Brittany N. Hoffman, Stavros G. Demos, John C. Lambropoulos   +3 more
doaj   +1 more source

Laser-direct-drive program: Promise, challenge, and path forward

Matter and Radiation at Extremes, 2017
Along with laser-indirect (X-ray)-drive and magnetic-drive target concepts, laser direct drive is a viable approach to achieving ignition and gain with inertial confinement fusion.
E.M. Campbell, V.N. Goncharov, T.C. Sangster, S.P. Regan, P.B. Radha, R. Betti, J.F. Myatt, D.H. Froula, M.J. Rosenberg, I.V. Igumenshchev, W. Seka, A.A. Solodov, A.V. Maximov, J.A. Marozas, T.J.B. Collins, D. Turnbull, F.J. Marshall, A. Shvydky, J.P. Knauer, R.L. McCrory, A.B. Sefkow, M. Hohenberger, P.A. Michel, T. Chapman, L. Masse, C. Goyon, S. Ross, J.W. Bates, M. Karasik, J. Oh, J. Weaver, A.J. Schmitt, K. Obenschain, S.P. Obenschain, S. Reyes, B. Van Wonterghem   +35 more
doaj   +1 more source

Comparison of different methods for evaluation of wind turbine power production based on wind measurements

Renewable Energy and Environmental Sustainability, 2016
Investigations of the wind shear up to the height of 200 (m) on the Latvian coast of the Baltic Sea have been carried out using a Pentalum SpiDAR laser measuring complex.
Bezrukovs Valerijs, Zacepins Aleksejs, Bezrukovs Vladislavs, Komasilovs Vitalijs   +3 more
doaj   +1 more source

Numerical Investigation of School Stratified Ventilation Systems - A Ventilation Effectiveness Study [PDF]

E3S Web of Conferences, 2019
Good indoor air quality is an essential prerequisite for a healthy learning environment. Scientific research has shown that there is a direct correlation between air quality and pupils’ ability to learn.
Adili Mohammad Reza, Engstfeld Simon, Stergiaropoulos Konstantinos   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Retracted Article: Road Traffic Monitoring System with Self-Learning Function using the Raspberry Pi Platform [PDF]

MATEC Web of Conferences, 2019
The authors, Cosmin Rus, Răzvan Marcuş and Olimpiu Stoicuța, regret that this article is an accidental duplication of an article that has already been published: https://www.mathworks.com/matlabcentral/fileexchange/52456-analyzing-trafficusing-a-webcam-a-
Rus Cosmin, Marcuş Răzvan, Stoicuța Olimpiu   +2 more
doaj   +1 more source