Results 51 to 60 of about 1,680,841 (298)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Two-Photon Absorption in Gapped Bilayer Graphene with a Tunable Chemical Potential
, 2016 Despite the now vast body of two-dimensional materials under study, bilayer graphene remains unique in two ways: it hosts a simultaneously tunable band gap and electron density; and stems from simple fabrication methods.
Abergel, D. S. L. +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Research into energy absorption of liquid cabin subjected to close-range explosion
Zhongguo Jianchuan Yanjiu, 2017 In order to study the energy absorption of different parts of a liquid cabin under a close-range explosion, a fluid-structure coupling model is built on the basis of experiments, and the deformation of the bulkhead and energy absorption ratio of ...
LI Siyu +3 more
doaj +1 more source
Research on Energy Dissipation Laws of Coal Crushing under the Impact Loads
Shock and Vibration, 2021 Dynamic crushing characteristics of coals are closely related with energy absorption and release of coals under certain strain rate. Hence, it is necessary to investigate energy dissipation laws of coal crushing under the impact loads with different ...
Dengke Xu +3 more
doaj +1 more source
Fracture and Structural Integrity, 2023 Safety Impact resistance is defined as the ability of a material to absorb impact energy through a controlled failure mechanism. The greater the energy absorption by the crash safety structure, the greater the safety in preventing deformation of the main
Andre Hartawan Mettanadi +4 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Ultrahigh Energy Absorption Multifunctional Spinodal Nanoarchitectures
Small, 2019 AbstractNanolattices are promoted as next‐generation multifunctional high‐performance materials, but their mechanical response is limited to extreme strength yet brittleness, or extreme deformability but low strength and stiffness. Ideal impact protection systems require high‐stress plateaus over long deformation ranges to maximize energy absorption ...
Anna Guell Izard +4 more
openaire +3 more sources
Experimental and numerical study on axial impact loading of pultruded composite tubes [PDF]
, 2007 The application of fibre reinforced composites has been increasing in the area of impact and blast loading of structures. The major advantages of these materials over metals are higher specific energy absorption, more economical, low weight and less ...
Palanivelu, Sivakumar
core +1 more source