Results 61 to 70 of about 8,281,901 (338)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Justification of a set of measures for forming an institutional environment and a management system for defense industry complex diversification

Управление
The wave-like nature of the state defense order confirms the need to diversify the defense enterprises’ activities as a way to improve their sustainability and development, which allows them to maintain the required level of the country’s defense ...
D. Yu. Baydarov, D. Yu. Faikov
doaj   +1 more source

Multiphysics Finite\u2013Element Modelling of an All\u2013Vanadium Redox Flow Battery for Stationary Energy Storage [PDF]

, 2015
All-Vanadium Redox Flow Batteries (VRFBs) are emerging as a novel technology for stationary energy storage. Numerical models are useful for exploring the potential performance of such devices, optimizing the structure and operating condition of cell ...
Bertucco, Alberto, Fiorenzato, V., Giomo, Monica, Guarnieri, Massimo, Moro, Federico   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Removal Energies and Final State Interaction in Lepton Nucleus Scattering

, 2019
We investigate the binding energy parameters that should be used in modeling electron and neutrino scattering from nucleons bound in a nucleus within the framework of the impulse approximation.
Bodek, Arie, Cai, Tejin
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

On the energy of homogeneous cosmologies

, 2008
An energy for the homogeneous cosmological models is presented. More specifically, using an appropriate natural prescription, we find the energy within any region with any gravitational source for a large class of gravity theories--namely those with a ...
A. Papapetrou, A. Trautman, C. Møller, C.-M. Chen, C. W. Misner, D. Kramer, D. R. Brill, F. W. Hehl, G. T. Horowitz, I. Radinschi, J. M. Nester, J. M. Nester, James M. Nester, L. B. Szabados, L. D. Landau, L. L. So, Lau Loi So, M. Janssen, M. G. Albrow, R. Geroch, R. P. Wallner, S. Feng, S. Weinberg, T. Vargas   +23 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source