Results 91 to 100 of about 7,358,194 (305)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ANALYSIS OF ENERGY BALANCE IN ELASTO-PLASTIC RESPONSE OF RC PIER DURING EARTHQUAKE [PDF]

open access: yes
Balance between external input energy and incoming internal strain and kinetic energy in the dynamic elasto-plastic response of RC pier during a strong earthquake, is discussed in this paper.
太田, 雅仁   +4 more
core  

EBS (Energy Balance Studio)

open access: yes
<p>The EBS (Energy Balance Studio) or Computer Model for the Energy Balance and Statistics is an effective tool for providing a systematic framework in organizing the energy statistics data that can be used for constructing inputs for energy ...
International Atomic Energy Agency
core   +1 more source

Energy laboratory data and model directory [PDF]

open access: yes, 1981
Over the past several years M.I.T. faculty, staff, and students have produced a substantial body of research and analysis relating to the production, conversion, and use of energy in domestic and international markets.
Carson, J., Lahiri, S.
core  

A Practical Method for Probabilistic Analysis of Electric Power and Energy Balance of New Power System [PDF]

open access: yesDianli jianshe
[Objective] The use of deterministic methods to construct power and energy balance tables is unsuitable because of the strong randomness and frequent occurrence of extreme events caused by a high proportion of new energy grid connections. [Methods] Based
LI Wanru, GUO Jincheng, WANG Jianxue, WANG Xiuli, YANG Qian, MA Qian
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Estimation of Building Parameters Using Simplified Energy Balance Model and Metered Whole Building Energy Use [PDF]

open access: yes, 2012
This paper presents and evaluates an indirect data-driven method to estimate influential building parameters: air exchange rates and overall heat transfer coefficients of building envelopes from the separately metered energy use for electricity, cooling ...
Masuda, H., Claridge, D.
core  

Energy balance of internal combustion engines using alternative fuels

open access: yes, 2013
This paper reviews the literature available concerning the energy balance of internal combustion engines operating on alternative fuels. Global warming and energy crisis are among the most important issues that threaten the peaceful existence of the man ...
Sanjid, A.   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Perceptions of Obesity and Treatment Decision‐Making Among Hispanic‐Latino Adults: Barriers to Metabolic and Bariatric Surgery

open access: yesObesity Science & Practice
Objective Metabolic and Bariatric Surgery (MBS) is underutilized among Hispanic‐Latino adults despite higher obesity rates and related comorbidities. Although barriers such as cost, language, and limited provider referrals are documented, sociocultural ...
Viviane Fornasaro‐Donahue   +2 more
doaj   +1 more source

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