Results 91 to 100 of about 728,565 (310)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
ANALYSIS OF ENERGY BALANCE IN ELASTO-PLASTIC RESPONSE OF RC PIER DURING EARTHQUAKE [PDF]
Balance between external input energy and incoming internal strain and kinetic energy in the dynamic elasto-plastic response of RC pier during a strong earthquake, is discussed in this paper.
太田, 雅仁 +4 more
core
Estimation of Building Parameters Using Simplified Energy Balance Model and Metered Whole Building Energy Use [PDF]
, 2012 This paper presents and evaluates an indirect data-driven method to estimate influential building parameters: air exchange rates and overall heat transfer coefficients of building envelopes from the separately metered energy use for electricity, cooling ...
Masuda, H., Claridge, D.
core
The effect of an incremental increase in exercise on appetite, eating behaviour and energy balance in lean men and women feeding ad libitum [PDF]
, 2008 Peer ...
King, Neil +11 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Materials & DesignTranscatheter aortic valve implantation (TAVI) is a revolutionary intervention for aortic stenosis, yet complications such as paravalvular leakage (PVL) and excessive tissue stress remain prevalent, particularly in anatomies with elliptical aortic roots.
Jingwen Zhang +7 more
doaj +1 more source
Substantial Balance Equation of Internal Energy as Viewed by the Balance Theory
Engineering Transactions, 2015 The article defines the microscopic substantial system and elementary first-order increments of elementary third-order increments of internal energy (IE), friction heat and heat exchanged between the substantial microsystem and the exterior.
Z. Wrzesiński
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source