Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Isospin effects on the system size dependence of balance energy in heavy-ion collisions
We study the effect of isospin degree of freedom on balance energy throughout the mass range between 50 and 350 for two sets of isobaric systems with N/A = 0.5 and 0.58.
Gautam, Sakshi, Sood, Aman D.
core +1 more source
Effects of negative energy balance on liver gene and protein expression during the early postpartum period and its impacts on dairy cow fertility [PDF]
End of project reportNegative energy balance (NEB) is a severe metabolic affecting high yielding dairy cows early post partum with both concurrent and latent negative effects on cow fertility as well as on milk production and cow health.
Diskin, Michael G. +9 more
core
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
THE INVOLVEMENT OF INFORMATION TECHNOLOGY IN THE OPTIMAL FUNCTIONING OF ELECTRIC DRIVE SYSTEMS [PDF]
The implementation of sustainable development in Romania and the abrupt increase of prices for fussil fuels have imposed more serious activies for the examination of the energy consumption in different industrial sectors.
Mihaela COCOSILÄ‚ +3 more
core
Jet measurements by the CMS experiment in pp and PbPb collisions
The energy loss of fast partons traversing the strongly interacting matter produced in high-energy nuclear collisions is one of the most interesting observables to probe the nature of the produced medium.
+5 more
core +1 more source
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Estimating the seasonal energy balance in Asian black bears and associated factors
Energy balance (i.e., energy intake minus energy expenditure) is an essential factor when evaluating an animal's nutritional state. We aimed to identify periods of the year that are most important for Asian black bears (Ursus thibetanus) in terms of ...
Shino Furusaka +5 more
doaj +1 more source
On the balance energy and nuclear dynamics in peripheral heavy-ion collisions
We present here the system size dependence of balance energy for semi-central and peripheral collisions using quantum molecular dynamics model. For this study, the reactions of $Ne^{20}+Ne^{20}$, $Ca^{40}+Ca^{40}$, $Ni^{58}+Ni^{58}$, $Nb^{93}+Nb^{93 ...
RAJEEV K. PURI, RAJIV CHUGH, Sood A. D.
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source

