Results 91 to 100 of about 7,340,357 (294)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

On the scaling of the energy gain of ICF targets [PDF]

open access: yesNuclear Fusion, 1995
A new gain model based on an adiabatic self-similar solution of the hydrodynamic equations is proposed for inertial confinement fusion (ICF) targets ignited by means of a thermonuclear spark at the fuel centre. The model is applied to analyse gain curves corresponding to fixed values of the implosion velocity Uim. It is shown that the adequate ignition
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

ENERGY GAIN BY MEANS OF RESONANCE IN THE TESLA COIL [PDF]

open access: yesAvtomobilʹnyj Transport (Harʹkov), 2016
An analytical review of publications on the problem, first formulated by Nikola Tesla, generating «free» energy from the air in the surrounding space has been presented.
Yu. Batygin   +3 more
doaj  

Zero energy homes: Combining energy efficiency and solar energy technologies

open access: yes, 2000
In a typical Florida house, air-conditioning accounts for about 35% of all the electricity the home uses. As the largest single source of energy consumption in Florida, a home's air-conditioning load represents the biggest energy challenge facing Florida
National Renewable Energy Laboratory (U.S.)
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

The Maximum Particle Energy Gain during Magnetic Reconnection

open access: yesThe Astrophysical Journal Letters
The factors that control the maximum energy attained by protons and electrons during magnetic reconnection are investigated analytically and using large-scale simulations with the kglobal model.
Zhiyu Yin   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

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