Results 151 to 160 of about 10,480,065 (303)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

FEL and Optical Klystron Gain for an Electron Beam with Oscillatory Energy Distribution [PDF]

, 2009
If the energy spread of a beam is larger then the Pierce parameter, the FEL gain length increases dramatically and the FEL output gets suppressed. We show that if the energy distribution of such a beam is made oscillatory on a small scale, the gain ...
Ding, Y., Stupakov, G., Huang, Z.
core  

Dietary Energy Density in Relation to Subsequent Changes of Weight and Waist Circumference in European Men and Women

, 2009
Background - Experimental studies show that a reduction in dietary energy density (ED) is associated with reduced energy intake and body weight.
Nita G Forouhi, Marianne Uhre Jakobsen, Saris, W.H., Masala, G, Du, H., Wareham, N.J., Jebb, Susan A, Wareham, Nicholas J, Vanessa Ginder, Sorensen, T., Jakobsen Marianne Uhre, Sørensen, TI, Tjønneland Anne, Nicholas J Wareham, Palli, D, van der Aa, A., Sørensen Thorkild I. A., Du, Huaidong, Wareham, N., Buijsse, Brian, Tjønneland, A, Jebb, S.A., Halkjaer, J, Masala Giovanna, Kim Overvad, Palli, Domenico, Feskens, Edith J M, Ginder, V., Palli Domenico, Jakobsen, MU, Halkjaer, Jytte, Masala, G., Saris, WH, Wim H M Saris, Annika Steffen, Ginder, Vanessa, Forouhi Nita G., Overvad, K., Steffen, A., Feskens, E.J.M., Forouchi, N.G., Forouhi, NG, Thorkild I A Sørensen, Wareham Nicholas J., Saris, Wim H M, Forouhi, Nita G, Steffen, Annika, Halkjær Jytte, Saris Wim H. M., Jebb, SA, Masala, Giovanna, Tjonneland, A., Du Huaidong, Edith J M Feskens, van der A, Daphne L, Giovanna Masala, Steffen Annika, Feskens, E.J., Domenico Palli, Huaidong Du, Buijsse, B, Ginder Vanessa, Jebb Susan A., Overvad Kim, Feskens Edith J. M., Forouhi, N.G., Jakobsen, Marianne Uhre, Daphne L van der A, Overvad, Kim, Sørensen, Thorkild I A, Overvad, K, Jakobsen, M.U., Van Der A, DL, Jytte Halkjaer, Tjønneland, Anne, Palli, D., Buijsse Brian, Sorensen, T.I., Ginder, V, van der A Daphne L., Buijsse, B., Steffen, A, Halkjaer, J., Du, H, Wareham, NJ, Anne Tjønneland, Brian Buijsse, Feskens, EJ, Susan A Jebb   +88 more
core   +1 more source

Friction Induced Energy Gain

In this work we show how friction enables a non-linear energy transfer in a slow-fast Hamiltonian system. We first introduce a paradigmatic system consisting of a weakly coupled fast and slow oscillator that gives rise to a non-linear resonance. We state known Assertions about this system and the conservation of energy in the slow variables.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Energy-resolution Study of Frisch-grid Ionization Chamber Using Multi-wire Proportional Chamber Readout

Yuanzineng kexue jishu
A Frisch-grid ionization chamber detector based on multi-wire proportional chamber readout is built. It is equipped with avalanche amplification while retaining the shielding characteristics of the Frisch-grid ionization chamber to pre-amplify the ...
YIN Xiaohao1,2, WEI Xianglun1, HUANG Xinjie1,2, ZOU Haichuan2,3, QIU Tianli1,2, HE Zhoubo1,2, YANG Yuansheng1,2, LI Zhijie1,2, LI Meng1,2, MA Peng1, YANG Herun1, LU Chengui1, HU Rongjiang1, DUAN Limin1
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source