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Glucocorticoid hormones and energy homeostasis
Hormone Molecular Biology and Clinical Investigation, 2014Abstract Glucocorticoids (GC) and their cognate intracellular receptor, the glucocorticoid receptor (GR), have been characterised as critical checkpoints in the endocrine control of energy homeostasis in mammals. Indeed, aberrant GC action has been linked to a variety of severe metabolic diseases, including obesity, insulin resistance ...
Roldan M, de Guia +2 more
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Brain Circuits Regulating Energy Homeostasis
The Neuroscientist, 2004For decades, increasingly sophisticated methods have been designed to address the problem of the involvement of the brain in the physiology of energy homeostasis and the pathogenesis of obesity. A vast number of experimental observations have been made from novel genetic and physiologic approaches that allowed the identification of metabolic hormones ...
Tamas L, Horvath +2 more
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Hypothalamic regulation of energy homeostasis
Best Practice & Research Clinical Endocrinology & Metabolism, 2002The co-ordinated regulation of food intake and energy expenditure takes place in the hypothalamic regions of the brain. Current understanding of the systems involved in this regulation suggests that, in the hypothalamus, there are two major groups of neuropeptides involved in orexigenic and anorexic processes.
Amanda, Sainsbury +2 more
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Energy homeostasis in the bone
Trends in Endocrinology & MetabolismThe bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases.
Min, Zhou +4 more
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Endocannabinoids and Energy Homeostasis
2007The body’s endogenous endocannabinoid system includes two endogenous agoni sts for cannabinoid-(CB)-l receptors, anadamide and 2-arachidonoyl-glycerol (2-AG). Both of these endocannabinoids (ECs) are fatty acid signals derived from cell membranes. They exert a coordinated action at multiple tissues to promote increased food intake, lipogenesis, and ...
Stephen C. Woods, Daniela Cota
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Potassium homeostasis and glial energy metabolism
Glia, 1997Since capillaries appear not to contribute significantly to rapid removal of K+ from brain tissue, the K+ released into extracellular clefts by neurons at the onset of electrical activity is presumably removed either by redistribution in the clefts or by uptake into cells.
T, Amédée, A, Robert, J A, Coles
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Kisspeptins: Bridging energy homeostasis and reproduction
Brain Research, 2010Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive disorders. The mechanisms for such a close connection between energy balance and reproduction have been the subject of considerable
Castellano, Juan M +3 more
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Regulation of Energy Homeostasis
Science, 2010The mammalian AMP-activated protein kinase (AMPK) is a serine/threonine kinase complex that regulates cellular energy homeostasis. However, the mechanisms by which AMPK mediates transcriptional responses to metabolic perturbations has been unclear. Bungard et al. (p. [1201][1]; published online 17 August; see the Perspective by [Hardie][2] ) have found
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Journal of Advanced Nutrition and Human Metabolism, 2018
A neuron-enriched secreting protein, NELL2 is a highly conserved molecule between rodents and human. With its several functional motifs, NELL2 has been suggested to play a critical role in embryonic neural development and neuronal protection. However, NELL2 function in adulthood brain has not been clearly understood until recently.
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A neuron-enriched secreting protein, NELL2 is a highly conserved molecule between rodents and human. With its several functional motifs, NELL2 has been suggested to play a critical role in embryonic neural development and neuronal protection. However, NELL2 function in adulthood brain has not been clearly understood until recently.
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Osteoblast Bioenergetics and Global Energy Homeostasis
2018The emergence of the endochondral skeleton in terrestrial animals enabled ambulation against increased gravitational forces and provided a storage site for scarce minerals essential for life. This skeletal upgrade increased overall fuel requirements and altered global energy balance, prompting the evolution of endocrine networks to coordinate energy ...
Angela R, Verardo, Thomas L, Clemens
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