Results 21 to 30 of about 796,482 (264)

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice

Scientific Reports, 2017
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is controversially discussed. Here, we investigated how various types of dietary fibre and different SCFA ratios affect metabolic syndrome-related disorders.
Karolin Weitkunat, Christin Stuhlmann, Anna Postel, Sandra Rumberger, Maria Fankhänel, Anni Woting, Klaus Jürgen Petzke, Sabrina Gohlke, Tim J. Schulz, Michael Blaut, Susanne Klaus, Sara Schumann   +11 more
doaj   +1 more source

Simulated Microgravity Potentiates Hematopoietic Differentiation of Human Pluripotent Stem Cells and Supports Formation of 3D Hematopoietic Cluster

Frontiers in Cell and Developmental Biology, 2022
Microgravity has been shown to induces many changes in proliferation, differentiation and growth behavior of stem cells. Little is known about the effect of microgravity on hematopoietic differentiation of pluripotent stem cells (PSCs). In this study, we
Chiyuan Ma, Yue Xiong, Pei Han, Xueying Zhang, Yujing Cao, Baobei Wang, Huashan Zhao, Enkui Duan, Jian V. Zhang, Jian V. Zhang, Xiaohua Lei, Xiaohua Lei   +11 more
doaj   +1 more source

Fibrinogen Fucosylation as a Prognostic Marker of End-Stage Renal Disease in Patients on Peritoneal Dialysis

Biomolecules, 2020
Glycosylation may strongly affect protein structure and functions. A high risk of cardiovascular complications seen in patients with end-stage renal disease (ESRD) is, at least partly associated with delayed clot formation, increased clot strength, and ...
Marko Baralić, Nikola Gligorijević, Voin Brković, Jaroslav Katrlík, Lucia Pažitná, Miloš Šunderić, Goran Miljuš, Ana Penezić, Zorana Dobrijević, Mirjana Laušević, Olgica Nedić, Dragana Robajac   +11 more
doaj   +1 more source

Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan

Nature Communications, 2022
Life- and healthspan of organisms can be modulated by dietary, genetic, or pharmacological interventions, which often affect metabolic pathways. Here the authors report that Grainyhead 1 is an evolutionarily conserved, drug-inducible transcription factor
Giovanna Grigolon, Elisa Araldi, Reto Erni, Jia Yee Wu, Carolin Thomas, Marco La Fortezza, Beate Laube, Doris Pöhlmann, Markus Stoffel, Kim Zarse, Erick M. Carreira, Michael Ristow, Fabian Fischer   +12 more
doaj   +1 more source

Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice

Frontiers in Cell and Developmental Biology, 2021
Hyperandrogenism is a key pathological feature of polycystic ovarian syndrome (PCOS). Excess androgen can lead to PCOS-like cell hypertrophy in the ovaries and adipose tissue of rodents.
Li-Feng Sun, Ya-Li Yang, Ya-Li Yang, Mei-Yue Wang, Mei-Yue Wang, Hua-Shan Zhao, Hua-Shan Zhao, Tian-xia Xiao, Meng-Xia Li, Bao-Bei Wang, Chen Huang, Chen Huang, Pei-Gen Ren, Pei-Gen Ren, Jian V. Zhang, Jian V. Zhang   +15 more
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A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging

Nature Communications, 2023
To ameliorate or even prevent signatures of aging in ultimately humans, we here report the identification of a previously undescribed polyacetylene contained in the root of carrots (Daucus carota), hereafter named isofalcarintriol, which we reveal as ...
Carolin Thomas, Reto Erni, Jia Yee Wu, Fabian Fischer, Greta Lamers, Giovanna Grigolon, Sarah J. Mitchell, Kim Zarse, Erick M. Carreira, Michael Ristow   +9 more
doaj   +1 more source

Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity

Cancer Biology & Medicine
Objective: Lung cancer is the leading cause of cancer-related deaths worldwide. Chemotherapy is associated with side effects, such as damage to myeloid cells and a reduction in the number of immune cells in patients.
Shumeng Lin, Liuliu Yuan, Xiao Chen, Shiyin Chen, Mengling Wei, Bingjie Hao, Tiansheng Zheng, Lihong Fan   +7 more
doaj   +1 more source

Energy in Ancient Metabolism [PDF]

Cell, 2017
Modern metabolism would not work without ATP and phosphate, but in primordial biochemical networks, energy currencies might have been simpler. Goldford et al. report a novel systems approach to reconstructing energetics in ancient metabolism, with very interesting results.
Martin, W., Thauer, R. ; https://orcid.org/0000-0003-0714-0148   +1 more
openaire   +3 more sources

NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation

Nature Communications
Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous signals shape ...
Stephan Dodt, Noah V. Widdershooven, Marie-Luise Dreisow, Lisa Weiher, Lukas Steuernagel, F. Thomas Wunderlich, Jens C. Brüning, Henning Fenselau   +7 more
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Lactate and Myocardiac Energy Metabolism

Frontiers in Physiology, 2021
The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic ...
Shuohui Dong, Linhui Qian, Zhiqiang Cheng, Chang Chen, Kexin Wang, Sanyuan Hu, Xiang Zhang, Tongzhi Wu, Tongzhi Wu   +8 more
doaj   +1 more source