Results 41 to 50 of about 223,481 (265)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
On spectra of unitary Cayley mixed graph [PDF]
Transactions on Combinatorics, 2016 In this paper we introduce mixed unitary Cayley graph $M_{n}$ $(n>1)$ and compute its eigenvalues. We also compute the energy of $M_{n}$ for some $n$.
Chandrashekar Adiga +1 more
doaj
On incidence energy of a graph
Linear Algebra and its Applications, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gutman, Ivan +3 more
openaire +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Oboudi-Type Bounds for Graph Energy [PDF]
Mathematics Interdisciplinary Research, 2019 The graph energy is the sum of absolute values of the eigenvalues of the (0, 1)-adjacency matrix. Oboudi recently obtained lower bounds for graph energy, depending on the largest and smallest graph eigenvalue. In this paper, a few more Oboudi-type bounds
Ivan Gutman
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
General Zagreb adjacency matrix [PDF]
Contributions to Mathematics, 2022 Zhen Lin
doaj +1 more source
Energy Conditions for Hamiltonian and Traceable Graphs
Universal Journal of Mathematics and Applications, 2019 A graph is called Hamiltonian (resp. traceable) if the graph has a Hamiltonian cycle (resp. path), a cycle (resp. path) containing all the vertices of the graph. The energy of a graph is defined as the sum of the absolute values of the eigenvalues of the
Rao Li
doaj +1 more source
Minimum Roman Dominating Distance Energy of a Graph
, 2022 In this correspondence, we introduced the concept of minimum roman dominating distance energy $E_{RDd}(G)$ of a graph $G$ and computed minimum roman dominating distance energy of some standard graphs. Also, we discussed the properties of eigenvalues of a minimum roman dominating distance matrix $A_{RDd}(G).$ Finally, we derived the Upper and lower ...
Lakshmanan, R., Annamalai, N.
openaire +3 more sources