Results 101 to 110 of about 1,660,548 (303)
Journal of Materials Research and Technology, 2019 This paper presents the thermo-elastic effect on materials having anisotropic behavior and stresses developed due to residual temperature on interlaminar delamination fracture characteristics of composite skin stiffener.
Saumya Shah +3 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The late time evolution of Gamma-Ray Bursts: ending hyperaccretion and producing flares
, 2006 We consider the properties of a hyperaccretion model for gamma-ray bursts (GRBs) at the late time when the mass supply rate is expected to decrease with time.
B. Zhang, D. Proga, Fuller
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Thermodynamical Description of Running Discontinuities: Application to Friction and Wear
Entropy, 2010 The friction and wear phenomena appear due to contact and relative motion between two solids. The evolution of contact conditions depends on loading conditions and mechanical behaviours.
Claude Stolz
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Delamination growth analysis in quasi-isotropic laminates under loads simulating low-velocity impact [PDF]
A geometrically nonlinear finite-element analysis was developed to calculate the strain energy released by delamination plates during impact loading. Only the first mode of deformation, which is equivalent to static deflection, was treated.
Elber, W., Shivakumar, K. N.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Reliability Analysis for the Gear Fracture based on Energy Release Rate Criterion
Jixie chuandong, 2015 Based on energy release rate criterion,a reliability analysis model is presented for the gear fracture. Firstly,the formula of gear fracture energy release rate is deduced,then the material parameter,crack size,load which affecting on gear fracture are ...
Song Ping, Song Feifei
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