A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Energy release rate for cracks in hydrogels undergoing finite deformations. [PDF]
J Mech Phys Solids, 2022 Garyfallogiannis K +2 more
europepmc +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Thermodynamical Description of Running Discontinuities: Application to Friction and Wear
Entropy, 2010 The friction and wear phenomena appear due to contact and relative motion between two solids. The evolution of contact conditions depends on loading conditions and mechanical behaviours.
Claude Stolz
doaj +1 more source
The Effect of the Energy Release Rate on the Local Damage Evolution in TRIP Steel Composite Reinforced with Zirconia Particles. [PDF]
Materials (Basel), 2022 Tseng SC +5 more
europepmc +1 more source
Photocrosslinked microgels for oral delivery of macromolecular based-therapeutics
, 2015 In this work we present the fabrication of planar micro-hydrogels serving as vehicle for oral delivery of poorly bioavailable drugs. Microfabricated gels were prepared by means of selective exposure of aqueous solutions of poly(vinylpyrrolidone) (PVP) to
Faralli, A. +7 more
core
Energy release rate analysis of interfacial cracks in composites
, 1989 Analytical methods have been developed to study the basic nature of the coupled opening, in-plane shearing, and antiplane shearing fracture behavior of an interfacial crack between two anisotropic media.
Manoharan, Muthuswamy Ganapathy
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Reliability Analysis for the Gear Fracture based on Energy Release Rate Criterion
Jixie chuandong, 2015 Based on energy release rate criterion,a reliability analysis model is presented for the gear fracture. Firstly,the formula of gear fracture energy release rate is deduced,then the material parameter,crack size,load which affecting on gear fracture are ...
Song Ping, Song Feifei
doaj
The energy release rate for non-penetrating crack in poroelastic body by fluid-driven fracture. [PDF]
Math Mech Solids, 2023 Kovtunenko VA, Lazarev NP.
europepmc +1 more source