Results 91 to 100 of about 495,021 (262)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Research on the Initiation and Propagation Modes of 3-D Crack Under Hydro-mechanical Coupling

工程科学与技术, 2018
It is easy for the cracks in rock masses to propagate and coalesce under the combination of high ground stress and seepage pressure, which leads to the failure of rock masses.
Lei YANG, Jie MEI, Shucai LI, Bangxiang LI, Kongling GUO, Bo ZHANG, Weimin YANG, Qiangyong ZHANG   +7 more
doaj  

Energy release rate for cracks in hydrogels undergoing finite deformations. [PDF]

J Mech Phys Solids, 2022
Garyfallogiannis K, Purohit PK, Bassani JL.   +2 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Energy release rate of small cracks in hyperelastic materials

, 2012
International audienceThe energy release rate of a small crack in an infinite hyperelastic medium, and subjected to large strain multiaxial loading conditions, is derived by considering the balance of configurational stresses acting on two planes: one ...
Mars, W. V., Aït-Bachir, Malik, Verron, Erwan   +2 more
core   +1 more source

Thermodynamical Description of Running Discontinuities: Application to Friction and Wear

Entropy, 2010
The friction and wear phenomena appear due to contact and relative motion between two solids. The evolution of contact conditions depends on loading conditions and mechanical behaviours.
Claude Stolz
doaj   +1 more source

The Effect of the Energy Release Rate on the Local Damage Evolution in TRIP Steel Composite Reinforced with Zirconia Particles. [PDF]

Materials (Basel), 2022
Tseng SC, Chiu CC, Qayyum F, Guk S, Chao CK, Prahl U.   +5 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The energy release rate for non-penetrating crack in poroelastic body by fluid-driven fracture. [PDF]

Math Mech Solids, 2023
Kovtunenko VA, Lazarev NP.
europepmc   +1 more source