Results 81 to 90 of about 478,588 (265)

Thermodynamical Description of Running Discontinuities: Application to Friction and Wear

Entropy, 2010
The friction and wear phenomena appear due to contact and relative motion between two solids. The evolution of contact conditions depends on loading conditions and mechanical behaviours.
Claude Stolz
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effect of the Energy Release Rate on the Local Damage Evolution in TRIP Steel Composite Reinforced with Zirconia Particles. [PDF]

Materials (Basel), 2022
Tseng SC, Chiu CC, Qayyum F, Guk S, Chao CK, Prahl U.   +5 more
europepmc   +1 more source

Reliability Analysis for the Gear Fracture based on Energy Release Rate Criterion

Jixie chuandong, 2015
Based on energy release rate criterion,a reliability analysis model is presented for the gear fracture. Firstly,the formula of gear fracture energy release rate is deduced,then the material parameter,crack size,load which affecting on gear fracture are ...
Song Ping, Song Feifei
doaj  

Lengthwise Crack Study of a Beam with Non-Linear Creep

Engineering Transactions
An analytical study of the strain energy release rate for an inhomogeneous beam structure with a lengthwise crack subjected to non-linear creep is developed. The beam is inhomogeneous along its length.
Victor Iliev RIZOV
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The energy release rate for non-penetrating crack in poroelastic body by fluid-driven fracture. [PDF]

Math Mech Solids, 2023
Kovtunenko VA, Lazarev NP.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An Experimental Study of the Relation between Mode I Fracture Toughness, K_Ic, and Critical Energy Release Rate, G_Ic. [PDF]

Materials (Basel), 2023
Qiao Y, Zhang ZX, Zhang S.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source