Results 81 to 90 of about 465,067 (266)

Reliability Analysis for the Gear Fracture based on Energy Release Rate Criterion

Jixie chuandong, 2015
Based on energy release rate criterion,a reliability analysis model is presented for the gear fracture. Firstly,the formula of gear fracture energy release rate is deduced,then the material parameter,crack size,load which affecting on gear fracture are ...
Song Ping, Song Feifei
doaj  

Energy release rate for cracks in hydrogels undergoing finite deformations. [PDF]

J Mech Phys Solids, 2022
Garyfallogiannis K, Purohit PK, Bassani JL.   +2 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Effect of the Energy Release Rate on the Local Damage Evolution in TRIP Steel Composite Reinforced with Zirconia Particles. [PDF]

Materials (Basel), 2022
Tseng SC, Chiu CC, Qayyum F, Guk S, Chao CK, Prahl U.   +5 more
europepmc   +1 more source

Energy release rate for non-smooth cracks in planar elasticity

Journal de l’École polytechnique — Mathématiques, 2015
This paper is devoted to the characterization of the energy release rate of a crack which is merely closed, connected, and with (length) density 1 / 2 at
Babadjian, Jean-François, Chambolle, Antonin, Lemenant, Antoine   +2 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The energy release rate for non-penetrating crack in poroelastic body by fluid-driven fracture. [PDF]

Math Mech Solids, 2023
Kovtunenko VA, Lazarev NP.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Experimental Study of the Relation between Mode I Fracture Toughness, K_Ic, and Critical Energy Release Rate, G_Ic. [PDF]

Materials (Basel), 2023
Qiao Y, Zhang ZX, Zhang S.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source