Results 111 to 120 of about 1,660,548 (303)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Energy release rate for cracks in hydrogels undergoing finite deformations. [PDF]

open access: yesJ Mech Phys Solids, 2022
Garyfallogiannis K   +2 more
europepmc   +1 more source

Dual conservation integrals and energy release rates

open access: yesInternational Journal of Solids and Structures, 2007
AbstractSimple derivation of the dual conservation integrals in small strain elasticity is presented, without the aid of Noether’s theorem on invariant variational principles. The derived integrals are related to the release rates of the potential and complementary potential energy associated with the defect motion.
Lubarda, V.A., Markenscoff, X.
openaire   +1 more source

Translational and extensional energy release rates (the J- and M-integrals) for a crack layer in thermoelasticity [PDF]

open access: yes
A number of papers have been presented on the evaluation of energy release rate for thermoelasticity and corresponding J integral. Two main approaches were developed to treat energy release rate in elasticity.
Chudnovsky, A., Gommerstadt, B.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mode 1 delamination growth in adhesively bonded joints under static and fatigue loads [PDF]

open access: yes
The objective of this investigation was to characterize the pure mode 1 delamination growth in metal to metal adhesively bonded joints under static and fatigue loading conditions, using FM 73 adhesive. Double cantilever beam specimens (DCB) were used for
Biswas, S. C., Jeelani, S.
core   +1 more source

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