Results 51 to 60 of about 11,796,944 (252)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Theoretical Study on Dynamic Energy Release Rate [PDF]

open access: yes, 1982
458This paper presents theoretical considerations on the expressions for the dynamic energy release rate in elastic crack, propagation. The validity of the expressions, which have been proposed by Erdogan, by Achenbach and by Freund, is discussed on the ...
90135541, 矢富, 盟祥, 9781
core  

Releasing chemical energy in spatially programmed ferroelectrics

open access: yesNature Communications, 2022
Chemical energy ferroelectrics show limited control of the energy release rate. Here, the authors design spatially programmed energetic ferroelectrics with controlled energy release rates from machine learning-directed additive manufacturing and ice ...
Yong Hu   +15 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Young’s Modulus and Hardness Identification of Extruded Aluminum by Scratching Damper

open access: yesMachines
A special vibration damper is proposed for Young’s modulus and hardness identification through a scratching process on extruded aluminum. This paper presents the design and working principle of a scratching damper based on a scratching device.
Chun-Nam Wong   +3 more
doaj   +1 more source

Numerical study of critical straight, frown, and chevron incisions in small incision cataract surgery

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Introduction: When an intraocular lens (IOL) injector is inserted through a pre-cut corneal incision (e.g., an empirical size of 2.2 mm) during small incision cataract surgery, uncontrollable tearing to the corneal tissue may occur, which is highly ...
Yang Han, Yang Han, Nan Qi, Nan Qi
doaj   +1 more source

Strain-rate-dependent microplane model for high-rate comminution of concrete under impact based on kinetic energy release theory

open access: yes, 2015
The apparent increase of strength of concrete at very high strain rates experienced in projectile impact (10 s(-1) to 10(6) s(-1)), called 'dynamic overstress', has recently been explained by the theory of release of local kinetic energy of shear strain ...
Kirane K   +3 more
core   +1 more source

Energy release rate and stress intensity factor in antiplane elasticity [PDF]

open access: yes, 2011
In the setting of antiplane linearized elasticity, we show the existence of the stress intensity factor and its relation with the energy release rate when the crack path is a C(1.1) curve.
Toader, R.   +5 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Numerical Investigation of Crack Suppression Strategies in Ultra-Thin Glass Substrates for Advanced Packaging

open access: yesMicromachines
The mechanical reliability of glass substrates is a key challenge for their adoption in advanced semiconductor packaging. This study employs finite element analysis to systematically evaluate the risk of edge crack propagation in large glass panels ...
Xuan-Bach Le   +2 more
doaj   +1 more source

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