Results 51 to 60 of about 465,067 (266)
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2021 In recent years, for the aim of weight reduction of transportation equipment, carbon fiber reinforced thermoplastics (CFRTPs), which have high recyclability and formability, are becoming suitable for mass production. Additionally, with the development of
Hiroki OTA +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MicromachinesThe mechanical reliability of glass substrates is a key challenge for their adoption in advanced semiconductor packaging. This study employs finite element analysis to systematically evaluate the risk of edge crack propagation in large glass panels ...
Xuan-Bach Le +2 more
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Experimental investigation of CFRP fracture toughness by delamination type
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2021 The results of analyzing fracture toughness in carbon fiber-reinforced plastics by the type of delamination are presented in the article. The goal of this paper is investigation of delamination propagation process and fracture mechanics parameters in ...
S. A. Chernyakin
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Effect of Metal on Composites Fatigue Damage in Mixed Structure [PDF]
Xibei Gongye Daxue Xuebao, 2018 This paper investigated the fatigue damage coupling of composite laminate and metallic plate in multi-bolt joint. A progressive fatigue damage model for composite laminates and a modified Lemaitre damage model for metal material were developed.
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Applied SciencesMode II (in-plane-shear) delamination tests are more complex than mode I (opening) due to the presence of a contact force between the two arms. This force is essential for the calculation of the energy release rate (ERR) and is closely linked to friction
Efstratios Polyzos +2 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source