Results 101 to 110 of about 3,743,775 (372)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Fiber echo state network analogue for high-bandwidth dual-quadrature signal processing.

Optics Express, 2019
All-optical platforms for recurrent neural networks can offer higher computational speed and energy efficiency. To produce a major advance in comparison with currently available digital signal processing methods, the new system would need to have high ...
M. Sorokina, S. Sergeyev, S. Turitsyn
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimization of multi-gigabit transceivers for high speed data communication links in HEP Experiments

, 2019
The scheme of the data acquisition (DAQ) architecture in High Energy Physics (HEP) experiments consist of data transport from the front-end electronics (FEE) of the online detectors to the readout units (RU), which perform online processing of the data ...
Das, Tushar Kanti, Khan, Shuaib Ahmad, Mitra, Jubin, Nayak, Tapan K.   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Planar Superconducting Whispering Gallery Mode Resonators

, 2013
We introduce a microwave circuit architecture for quantum signal processing combining design principles borrowed from high-Q 3D resonators in the quantum regime and from planar structures fabricated with standard lithography.
Devoret, M. H., Minev, Z. K., Pop, I. M.
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Energy-Efficient Future Wireless Networks: A Marriage between Massive MIMO and Small Cells

, 2015
How would a cellular network designed for high energy efficiency look like? To answer this fundamental question, we model cellular networks using stochastic geometry and optimize the energy efficiency with respect to the density of base stations, the ...
Björnson, Emil, Kountouris, Marios, Sanguinetti, Luca   +2 more
core   +3 more sources

Nonlocal Metasurfaces for Optical Signal Processing.

Physical Review Letters, 2018
Optical analog signal processing has been gaining significant attention as a way to overcome the speed and energy limitations of digital techniques. Metasurfaces offer a promising avenue towards this goal due to their efficient manipulation of optical ...
H. Kwon, D. Sounas, Andrea Cordaro, A. Polman, A. Alú   +4 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source