Results 121 to 130 of about 3,534,835 (366)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Design of X-ray energy detector

open access: yesEnergy Reports, 2022
Energy is an essential key element in the process of human survival and development. With the development and progress of science and technology, human beings pushed the age to the industrial period by discovering and exploiting coal. And then, all kinds
Fan Zeng, Zhiyuan Zhu
doaj  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Improvement of the GERDA Ge Detectors Energy Resolution by an Optimized Digital Signal Processing

open access: yesPhysics Procedia, 2015
AbstractGERDA is a new generation experiment searching for neutrinoless double beta decay of 76Ge, operating at INFN Gran Sasso Laboratories (LNGS) since 2010. Coaxial and Broad Energy Germanium (BEGe) Detectors have been operated in liquid argon (LAr) in GERDA Phase I.
Giovanni Benato   +4 more
openaire   +3 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Spatiotemporal Sensitive Network for Non-Contact Heart Rate Prediction from Facial Videos

open access: yesApplied Sciences
Heart rate (HR) is an important indicator reflecting the overall physical and mental health of the human body, playing a crucial role in diagnosing cardiovascular and neurological diseases.
Liying Su   +8 more
doaj   +1 more source

Signal Processing for Radiation Detectors

open access: yes, 2017
This book provides a clear understanding of the principles of signal processing of radiation detectors. It puts great emphasis on the characteristics of pulses from various types of detectors and offers a full overview on the basic concepts required to ...
M. Nakhostin
semanticscholar   +1 more source

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