Results 71 to 80 of about 396,456 (315)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Improved Multi-Grained Cascade Forest Model for Transformer Fault Diagnosis

CSEE Journal of Power and Energy Systems
Dissolved gas analysis (DGA) is an effective online fault diagnosis technique for large oil-immersed transformers. However, due to the limited number of DGA data, most deep learning models will be overfitted and the classification accuracy cannot be ...
Yiyi Zhang, Yuxuan Wang, Jiefeng Liu, Heng Zhang, Xianhao Fan, Dongdong Zhang   +5 more
doaj   +1 more source

Optimal control and robust estimation for ocean wave energy converters [PDF]

, 2013
This thesis deals with the optimal control of wave energy converters and some associated observer design problems. The first part of the thesis will investigate model predictive control of an ocean wave energy converter to maximize extracted power.
Abraham, Edo
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Evolutionary Synthesis of HVAC System Configurations: Algorithm Development. [PDF]

, 2008
This paper describes the development of an optimization procedure for the synthesis of novel heating, ventilating, and air-conditioning (HVAC) system configurations. Novel HVAC system designs can be synthesized using model-based optimization methods. The
Angelov, Plamen, Yi Zhang (9093), Jonathan Wright, Wright, Jonathan A., Richard Buswell, Plamen Angelov, Hanby, Victor I., Victor I. Hanby (7176788), Zhang, Yi, Yi Zhang, Jonathan Wright (1257306), Plamen Angelov (5037638), Richard Buswell (1249932), Buswell, Richard A., Victor Hanby   +14 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cost of energy and mutual shadows in a two-axis tracking PV system

, 2012
The performance improvement obtained from the use of trackers in a PV system cannot be separated from the higher requirement of land due to the mutual shadows between generators.
Perpiñan Lamigueiro, Oscar
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Grey Relational Analysis for Insulation Condition Assessment of Power Transformers Based Upon Conventional Dielectric Response Measurement

Energies, 2017
Conventional dielectric response measurement techniques, for instance, recovery voltage measurement (RVM), frequency domain spectroscopy (FDS) and polarization–depolarization current (PDC) are effective nondestructive insulation monitoring techniques for
Jiefeng Liu, Hanbo Zheng, Yiyi Zhang, Hua Wei, Ruijin Liao   +4 more
doaj   +1 more source