Results 101 to 110 of about 323,837 (316)

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Energy dependence of the GAFCHROMIC LD‐V1 in the diagnostic radiographic modalities

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract The GAFCHROMIC LD‐V1 radiochromic film is widely used in dosimetry because it can provide high‐resolution two‐dimensional dose distributions without processing. This study aimed to evaluate the response characteristics at different effective energies, from the low‐energy range of mammography to the high‐energy range of computed tomography. Net
Tatsuhiro Gotanda   +9 more
wiley   +1 more source

On the means, costs, and system-level impacts of 24/7 carbon-free energy procurement

open access: yesEnergy Strategy Reviews
A growing number of public and private energy buyers are interested in 24/7 carbon-free energy (CFE) procurement, which means that every kilowatt-hour of electricity consumption is met by carbon-free sources at all times. It has the potential to overcome
Iegor Riepin, Tom Brown
doaj  

Energy and transformation [PDF]

open access: yesNature Sustainability, 2019
openaire   +1 more source

Long‐term stability analysis of beam shape in a robotic radiosurgery system

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aimed to investigate the long‐term stability of CyberKnife beam profile parameters and assess their compliance with existing quality assurance (QA) guidelines. We evaluated beam profiles in both standard and diagonal planes over 3.5 years post‐installation to detect potential issues and ensure consistent beam quality.
Ryoichi Hinoto   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy