Results 101 to 110 of about 10,533,673 (391)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Green energy and steel imports reduce Europe’s net-zero infrastructure needs

open access: yesNature Communications
Importing renewable energy to Europe may offer many potential benefits, including reduced energy costs, lower pressure on infrastructure development, and less land use within Europe.
Fabian Neumann   +2 more
doaj   +1 more source

Rescaling the nonadditivity parameter in Tsallis thermostatistics

open access: yes, 2017
The paper introduces nonadditivity parameter transformation group induced by Tsallis entropy. We discuss simple physical applications of a system in the contact with finite heat bath or with temperature fluctuations.
Korbel, Jan
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

On the means, costs, and system-level impacts of 24/7 carbon-free energy procurement

open access: yesEnergy Strategy Reviews
A growing number of public and private energy buyers are interested in 24/7 carbon-free energy (CFE) procurement, which means that every kilowatt-hour of electricity consumption is met by carbon-free sources at all times. It has the potential to overcome
Iegor Riepin, Tom Brown
doaj   +1 more source

The great transformation: decarbonising Europeâ??s energy and transport systems [PDF]

open access: yes
The euro-area crisis dominates the economic news. Yet, the world and Europe may face even more important challenges that will shape our lives and the lives of our children.World population is projected to increase to 9 billion or more by 2050.
Anta Ndoye   +6 more
core   +1 more source

Poland’s energy security during the transformation process in comparison with the EU countries [PDF]

open access: diamond, 2023
Anna Bluszcz   +3 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Accelerating the transition from coal to renewables in Indonesia to achieve a net‐zero energy system

open access: yesIET Renewable Power Generation
Historically heavily reliant on coal, Indonesia is at a crucial juncture to accelerate its transition to renewable energy in order to meet its net‐zero goals.
Ashish Gulagi   +8 more
doaj   +1 more source

Energy security and energy transformation as impulses of global, regional and national civilization challenges

open access: yesVestnik of Vitebsk State Technological University
The article addresses the issue of the foundations of the idea of energy security at the global, continental and national levels, as well as the energy transformation necessary to achieve it, which is important for the modern world – both in terms of its
Marina L. Zelenkevich   +1 more
doaj   +1 more source

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