Results 101 to 110 of about 835,140 (307)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Quantification of low concentrations of sodium borohydride in solution

Next Energy
Sodium borohydride (NaBH4) has been identified as a potential solid-state hydrogen storage material for energy export due to its high gravimetric hydrogen content of ≈ 10.8 wt%.
Aneeka Patel, Peter Ó Conghaile, Terry D. Humphries, Mark Paskevicius, Craig E. Buckley   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Assessing energy transition in Mediterranean islands. A review

[EN] Touristic islands around the world are facing crucial energy challenges, including fossil fuel dependency, high electricity costs, high environmental impact and vulnerability to EU climate change targets and policies.
Andrada-Monrós, Clara, León-Martínez, Vicente, Valencia-Salazar, Iván, Peñalvo-López, Elisa   +3 more
core   +1 more source

Transient and Steady-State Evaluation of Distributed Generation in Medium-Voltage Distribution Networks

Energies
As power generation systems with increasingly higher capacities are interconnected with distribution networks, a pressing need arises for a thorough analysis of their integration and the subsequent impacts on medium-voltage lines.
Daniel Guillén-López, Xavier Serrano-Guerrero, Antonio Barragán-Escandón, Jean-Michel Clairand   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Pathways to a Fast and Just Energy Transition: Insights from Clean Energy Case Studies

The clean energy transition continues to gather pace and scale, despite push back from some quarters. The key challenge is therefore not whether it will happen but how to shape it in favour of greater speed, justice, and shared prosperity ...
Zuluaga, Mateo Adarve, Dalabajan, Dante, Mayne, Ruth   +2 more
core   +1 more source

Advances in Hosting Capacity Assessment and Enhancement Techniques for Distributed Energy Resources: A Review of Dynamic Operating Envelopes in the Australian Grid

Energies
The increasing penetration of distributed energy resources (DERs) such as solar photovoltaic (PV) systems, battery energy storage systems (BESSs), and electric vehicles (EVs) in low-voltage (LV) and medium-voltage (MV) distribution networks is reshaping ...
Naveed Ali Brohi, Gokul Thirunavukkarasu, Mehdi Seyedmahmoudian, Kafeel Ahmed, Alex Stojcevski, Saad Mekhilef   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Minireview: Intensified Low-Temperature Fischer–Tropsch Reactors for Sustainable Fuel Production

Fuels
Low-temperature Fischer–Tropsch (LTFT) synthesis converts syngas to diesel/wax at 200–250 °C. The LTFT reaction has recently received renewed interest, as it can be used for converting syngas from renewable sources (biomass and waste) to high-value fuels
Yadolah Ganjkhanlou, Evert Boymans, Berend Vreugdenhil   +2 more
doaj   +1 more source