Results 111 to 120 of about 835,140 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Energy efficiency in transition: do market-oriented economic reforms matter?

Global climate change and security of supply concerns pose significant challenges for sustainable development as well as the need to improve energy efficiency in transition and developing economies.
Nepal, Rabindra
core  

Unjust Transition: Reclaiming the energy future from climate colonialism

The global energy transition stands at a pivotal moment: it can either dismantle the inequalities driving the climate crisis or deepen them.
Ruiz, Valeska, Chester Pagulayan, Joel, Stroot, Hilde, Shortall, Natalie, Adarve Zuluaga, Mateo, Fadel Diop, Mohamadou, Wayand, Naira, Emran Hasan, Mohammad   +7 more
core   +1 more source

Building a ‘Fair and Fast’ energy transition? Renewable energy employment, skill shortages and social licence in regional areas [PDF]

Within techno-economic models for climate and energy scenarios, labour is assumed to be available just-in-time – even as cost-optimisation electricity system modelling typically generates development profiles with sharp peaks and troughs which would make
Rutovitz, J, Nagrath, K, Briggs, C, Langdon, R, Gill, J, Atherton, A   +5 more
core   +1 more source

Optimization Techniques for Home Energy Management Systems: A Comprehensive Review, Critical Analysis, and Future Directions

Urban Science
The increasing integration of renewable energy sources, smart appliances, and distributed energy technologies has significantly increased the complexity of residential energy systems, necessitating advanced Home Energy Management Systems (HEMS ...
Md Mamun Ur Rashid, Jiefeng Hu, Md Alamgir Hossain, Nima Amjady, Syed Islam   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Calibrated Physics-Based Dynamic Energy Modelling of an Airport Terminal

Buildings
This study developed a calibrated, data-supported energy simulation model for the Arrivals Terminal of Cluj-Napoca International Airport (Romania), addressing challenges in modelling complex building typologies.
Ancuța Maria Măgurean, Dan Doru Micu
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A New Euro-Mediterranean Energy Roadmap for a Sustainable Energy Transition in the Region. MEDPRO Policy Paper No. 3, February 2013 [PDF]

, 2013
This paper addresses the urgent need for a sustainable energy transition in the southern and eastern Mediterranean region. It analyses the unsustainable burden of universal energy subsidies and calls for new development paths unlocking the huge potential
Tagliapietra, Simone, Hafner, Manfred
core