Results 61 to 70 of about 56,592 (210)
Screening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compounds [PDF]
, 2015 Solid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the vascular system.
García-Vilas García, Javier Alejandro +2 more
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Fraternidad política y enfermedades raras
Araucaria, 2021 sumen Las enfermedades raras reciben, en general, menos financiación para su investigación y tratamientos médicos que el resto de enfermedades. Al margen de explicaciones científicas y económicas conocidas, existen dos grandes posiciones éticas respecto a este hecho, la que lo aprueba por razones de ética utilitarista, y la que lo condena insistiendo ...
openaire +5 more sources
Age‐specific melanoma risk associated with nevi: a pooled analysis from the M‐SKIP project
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Objective This study investigates the association of melanoma risk with total‐body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals. Methods A pooled analysis was conducted within the M‐SKIP project, based on multiple melanoma case‐control studies.
Giulia Doi +20 more
wiley +1 more source
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention [PDF]
, 2017 The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the hallmarks of cancer.
Carrillo, Paloma +7 more
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Entomologia Experimentalis et Applicata, EarlyView.Spring–Summer spatial dynamics of Palomena prasina (L.) and potential IPM strategies. ABSTRACT Palomena prasina (L.) (Hemiptera: Pentatomidae), the green shield bug (GSB), is an important hazelnut pest in Southern Europe. Currently, its control focuses on insecticide spraying during the crop season. We hypothesized that, as for other pentatomid species,
Laetitia Driss +4 more
wiley +1 more source
Orphanet Journal of Rare DiseasesBackground The low prevalence of rare diseases poses a significant challenge in advancing their understanding. This study aims to delineate the clinical and genetic characteristics of patients with rare eye diseases (RED) enrolled in the Spanish Rare ...
Alberto Lopez-de la Rosa +6 more
doaj +1 more source
Scientific Reports, 2021 High-throughput gene expression analysis is widely used. However, analysis is not straightforward. Multiple approaches should be applied and methods to combine their results implemented and investigated.
Fernando M. Jabato +9 more
doaj +1 more source
Interplay between glucose and palmitate uptake in breast carcinoma in vitro [PDF]
, 2018 One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect.
Carrillo, Paloma +4 more
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Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Epilepsia, EarlyView.Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa +17 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2022 Background Neurodegeneration with brain iron accumulation (NBIA) is a group of rare neurogenetic disorders frequently associated with iron accumulation in the basal nuclei of the brain characterized by progressive spasticity, dystonia, muscle rigidity ...
Mónica Álvarez-Córdoba +10 more
doaj +1 more source