Results 11 to 20 of about 8,151 (239)

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment. [PDF]

Adv Sci (Weinh)
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Shen Y, Huang Y, Zhang Y, Yu C, Liu H, Bian D, Wu D, Wang W, Ji X, Zheng Y, Jiang M, Li M.   +11 more
europepmc   +2 more sources

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document. [PDF]

Eur J Heart Fail
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Abdin A, Bauersachs J, Abdelhamid M, Aktaa S, Al Ghorani H, Bayes-Genis A, Biegus J, Böhm M, Butler J, Girerd N, Metra M, Mullens W, Skouri H, Vaduganathan M, El Hadidi S, Rosano GMC, Savarese G.   +16 more
europepmc   +2 more sources

Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke. [PDF]

CNS Neurosci Ther
Downregulation of H19 enhances angiogenesis and mitigates BBB damage by regulating IMP2, thereby alleviating cerebral I/R injury. Abstract Aims This study aimed to explore the effects of long noncoding RNA (lncRNA) H19 knockdown on angiogenesis and blood–brain barrier (BBB) integrity following cerebral ischemia/reperfusion (I/R) and elucidate their ...
Zhong L, Fan J, Yan F, Yang Z, Hu Y, Li L, Wang R, Zheng Y, Luo Y, Liu P.   +9 more
europepmc   +2 more sources

Pharmacokinetics and safety of prolonged paracetamol treatment in neonates: An interventional cohort study

British Journal of Clinical Pharmacology, Volume 89, Issue 11, Page 3421-3431, November 2023., 2023
Aims To investigate the pharmacokinetics and safety of prolonged paracetamol use (>72 h) for neonatal pain. Methods Neonates were included if they received paracetamol orally or intravenously for pain treatment. A total of 126 samples were collected. Alanine aminotransferase and bilirubin were measured as surrogate liver safety markers. Paracetamol and
Sissel Haslund‐Krog, Jessica M. Barry, Angela K. Birnbaum, Kim Dalhoff, Tine Brink Henriksen, Catherine M. T. Sherwin, Charul Avachat, Susanne Poulsen, Ulla Christensen, Rory P. Remmel, Diana Wilkins, John N. van den Anker, Helle Holst   +12 more
wiley   +1 more source

Effects of N2O elimination on the elimination of second gases in a two‐step mathematical model of heterogeneous gas exchange

Physiological Reports, Volume 11, Issue 21, November 2023., 2023
Effects of N2O elimination on the elimination of second gases in a two‐step mathematical model of heterogeneous gas exchange. Abstract We have investigated the elimination of inert gases in the lung during the elimination of nitrous oxide (N2O) using a two‐step mathematical model that allows the contribution from net gas volume expansion, which occurs ...
Ben Korman, Ranjan K. Dash, Philip J. Peyton   +2 more
wiley   +1 more source

Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence‐based prediction, expert evaluation, clinical corroboration and mechanism of action analyses

Addiction, Volume 118, Issue 7, Page 1307-1319, July 2023., 2023
Abstract Background and aims Cocaine use disorder (CUD) is a significant public health issue for which there is no Food and Drug Administration (FDA) approved medication. Drug repurposing looks for new cost‐effective uses of approved drugs. This study presents an integrated strategy to identify repurposed FDA‐approved drugs for CUD treatment.
Zhenxiang Gao, T. John Winhusen, Maria Gorenflo, Udi E. Ghitza, Pamela B. Davis, David C. Kaelber, Rong Xu   +6 more
wiley   +1 more source

Development and evaluation of a novel combined perfusion decellularization heart‐lung model for tissue engineering of bioartificial heart‐lung scaffolds

Artificial Organs, Volume 47, Issue 3, Page 481-489, March 2023., 2023
We present a novel model of combined perfusion and decellularization of heart‐lung organ‐blocs in a modified Langendorff circuit. Combined heart‐lungs organ blocs retrieved from rats were successfully decellularized to create an acellular scaffold with preserved extracellular matrix to provide a bioartificial platform for combined heart and lung tissue
Alina Zubarevich, Anja Osswald, Lukman Amanov, Arian Arjomandi Rad, Bastian Schmack, Arjang Ruhparwar, Alexander Weymann   +6 more
wiley   +1 more source

Alterações transitórias do exame neurológico durante o despertar da anestesia com enflurano, isoflurano ou sevoflurano Alteraciones transitorias del examen neurológico durante el despertar de la anestesia con enflurano, isoflurano o sevoflurano Transient neurological changes during emergence from enflurane, isoflurane or sevoflurane anesthesia

Revista Brasileira de Anestesiologia, 2001
JUSTIFICATIVA E OBJETIVOS: Anormalidades transitórias do exame neurológico ocorrem durante o despertar da anestesia com halotano, enflurano e isoflurano.
Luiz Fernando Soares, Pablo Escovedo Helayel, Getúlio Rodrigues de Oliveira Filho, Rogério do Amaral   +3 more
doaj   +1 more source

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics

BMC Anesthesiology, 2002
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis.
Levitt David G
doaj   +1 more source