Results 11 to 20 of about 7,819 (220)
Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke. [PDF]
CNS Neurosci TherDownregulation of H19 enhances angiogenesis and mitigates BBB damage by regulating IMP2, thereby alleviating cerebral I/R injury. Abstract Aims This study aimed to explore the effects of long noncoding RNA (lncRNA) H19 knockdown on angiogenesis and blood–brain barrier (BBB) integrity following cerebral ischemia/reperfusion (I/R) and elucidate their ...
Zhong L +9 more
europepmc +2 more sources
British Journal of Clinical Pharmacology, Volume 89, Issue 11, Page 3421-3431, November 2023., 2023 Aims To investigate the pharmacokinetics and safety of prolonged paracetamol use (>72 h) for neonatal pain. Methods Neonates were included if they received paracetamol orally or intravenously for pain treatment. A total of 126 samples were collected. Alanine aminotransferase and bilirubin were measured as surrogate liver safety markers. Paracetamol and
Sissel Haslund‐Krog +12 more
wiley +1 more source
Physiological Reports, Volume 11, Issue 21, November 2023., 2023 Effects of N2O elimination on the elimination of second gases in a two‐step mathematical model of heterogeneous gas exchange. Abstract We have investigated the elimination of inert gases in the lung during the elimination of nitrous oxide (N2O) using a two‐step mathematical model that allows the contribution from net gas volume expansion, which occurs ...
Ben Korman +2 more
wiley +1 more source
Addiction, Volume 118, Issue 7, Page 1307-1319, July 2023., 2023 Abstract Background and aims Cocaine use disorder (CUD) is a significant public health issue for which there is no Food and Drug Administration (FDA) approved medication. Drug repurposing looks for new cost‐effective uses of approved drugs. This study presents an integrated strategy to identify repurposed FDA‐approved drugs for CUD treatment.
Zhenxiang Gao +6 more
wiley +1 more source
Artificial Organs, Volume 47, Issue 3, Page 481-489, March 2023., 2023 We present a novel model of combined perfusion and decellularization of heart‐lung organ‐blocs in a modified Langendorff circuit. Combined heart‐lungs organ blocs retrieved from rats were successfully decellularized to create an acellular scaffold with preserved extracellular matrix to provide a bioartificial platform for combined heart and lung tissue
Alina Zubarevich +6 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 29, Issue 3, Page 866-877, March 2023., 2023 Three days’ RIPC mitigates I/R injury by decreasing the induction of JAK2/STAT3 pathway and cell cycle regulators cyclin D1 and CDK6 by MCAO, and this net inhibition of cell cycle re‐entry by RIPC is associated with downregulation of STAT3 phosphorylation. Abstract Aims Remote ischemic pre‐conditioning (RIPC) protects against ischemia/reperfusion (I/R)
Yongmei Zhao +13 more
wiley +1 more source
Effects of maternal enflurane exposure on NR2B expression in the hippocampus of their offspring
Brazilian Journal of Pharmaceutical Sciences, 2015 This work aims to study the pathogenesis of learning and memory impairment in offspring rats resulting from maternal enflurane anesthesia by focusing on the expression of the N-methyl-d-aspartic acid receptor subunit 2B (NR2B) in the hippocampus of the ...
Fo-Quan Luo +6 more
doaj +1 more source
Veterinary Medicine and Science, Volume 9, Issue 1, Page 37-42, January 2023., 2023 Jaw stiffness and apnoea in a dog with muscle rigidity during recovery from fentanyl‐ and sevoflurane‐based general anaesthesia for emergency abdominal surgery. Abstract A 22.5‐kg, 8.4‐year‐old female mixed breed dog was presented for an emergency ovariohysterectomy for pyometra.
Kazumasu Sasaki +4 more
wiley +1 more source
Jurnal Anestesi Perioperatif, 2015 Different volatile agents with different physicochemical properties affect uterine contraction, amount of bleeding, and APGAR score in different ways. The objective of this study was to evaluate the effects of different volatile agents, i.e., sevoflurane
RR. Pramada Resvita +2 more
doaj +1 more source
British Journal of Pharmacology, Volume 180, Issue 2, Page 235-251, January 2023., 2023 Abstract Background and Purpose Transient receptor potential melastatin type‐8 (TRPM8) is a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels. Here, we reveal the molecular mechanism of TRPM8 and its clinical relevance in colorectal cancer (CRC).
Ester Pagano +21 more
wiley +1 more source