Results 111 to 120 of about 1,219,757 (285)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Editorial: To engage or not to engage

, 2012
An introduction to the journal is presented in which the author discusses various reports published within the issue including one regarding sabermetrics approach in assembling a competitive baseball team, another by Jane Watson and Beth Chance that focuses on the appropriate content from probability and statistics for a school mathematics curriculum ...
Stillman, Gloria, Brown, Jill
openaire   +1 more source

Contributors

Engaged Scholar Journal, 2021
Engaged Scholar Journal
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

To engage or not to engage? [PDF]

Nature Climate Change, 2019
openaire   +1 more source

Students as Engaged Partners in Directed Research Courses [PDF]

This report from the field reflects on the authors’ experiences in a directed research course on the topic of youth civic engagement in Canada. A literature review was co-written as part of a directed research course where the instructor was a visiting ...
Jodi Benenson, Skylar Johnson, Benenson, Jodi, Johnson, Skylar   +3 more
core   +1 more source

Todo arte es Revolución: Actuación Global y Cambio Social

Pensamiento Palabra y Obra, 2017
El teatro puede ser un medio de transformación tanto personal como social. Este artículo examina la teoría y describe las prácticas necesarias para articular la confluencia de diversos aspectos del arte como activismo. Esta aplicación específica del arte
Jessica Litwak
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Engaging with engagement and coproduction

Research in Social and Administrative Pharmacy, 2023
Watson, Mags, Kjome, Reidun Lisbet S.
openaire   +1 more source