Results 101 to 110 of about 1,219,757 (285)

Engaged Environmental Citizenship [PDF]

, 2013
The topic of this book, engaged environmental citizenship, is a 'big idea'. It raises many issues about democracy; governance; consumer society; how people, their environments and ecology are connected; and how we can take better account of ecological ...
Lockie, Stewart, Aslin, Heather J.
core   +1 more source

Sòrò-Sókè: A Framing Analysis of Creative Resistance During Nigeria’s #EndSARS Movement

Journalism and Media
This study examines the role of creative resistance, or “artivism”, in Nigeria’s #EndSARS movement, a youth-led campaign against police brutality that peaked in October 2020.
Taiwo Afolabi, Friday Gabriel
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Drawing teacher identity: Perspectives of students in a teacher education program

Social Sciences and Humanities Open
Teacher identity significantly influences pedagogical decisions, classroom practices, and professional development. Understanding the development of preservice teacher identity is particularly important during initial teacher education, as it involves ...
Minsun Shin, Laurel Weston Alpern
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Faith and Engaged Scholarship in the New Millennium

, 2017
Despite the prominence of the “secularization thesis” among academics prior to the turn of the millennium, religion is not in decline worldwide. The Pew Research Center’s (2015) estimates show that until at least 2050 the number of people practicing a ...
Alisha Pomazon, Christopher Hrynkow, Rich Janzen   +2 more
core   +1 more source

Engaged learning in MOOCs: a study using the UK Engagement Survey

, 2015
This study sets out to answer the question: how can we know what learning is taking place in MOOCs? From this starting point, the study then looks to identify MOOCs’ potential for future use in HE?
Davis, Hugh C., Wintrup, Julie, Wakefield, Kelly   +2 more
core   +1 more source