Results 91 to 100 of about 1,183,219 (205)

Modeling Textual Emotions in Literary Fiction

Digital Humanities in the Nordic and Baltic Countries Publications
This paper explores how finetuned transformer models can be used to examine the vast and underexplored emotional-historical dimensions of literary history.
Kirstine Nielsen Degn, Alexander Conroy, Xiaoyuan Jiang, Ali Al-Laith, Jens Bjerring-Hansen, Tanya Karoli Christensen, Ingo Zettler, Daniel Hershcovich   +7 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Making and interpreting: digital humanities as embodied action

Humanities & Social Sciences Communications
Digital technology has created new spaces, new realities and new ways of life, which have changed the way people perceive and recognise the world. In particular, the production, dissemination and reception methods of literature and art have been impacted
Zhiqing Zhang, Wanyi Song, Peng Liu
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

‘Translating’ Classics for Generations Z and Alpha

The Journal of Classics Teaching
This paper presents a public outreach program developed by the Department of Classics at the University of Florida to introduce school-age children to Classics.
Eleni Bozia, Anastasia Pantazopoulou, Anthony J. Smith   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Operative and predicative forms of knowledge [PDF]

Investigações em Ensino de Ciências, 2012
The major aim of this paper is to approach ideas that stem from lessons I have been able to learn from the most diverse types of experiences, especially from the research on psychology and on the and didactics of mathematics in which I have been ...
Gérard Vergnaud
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The humanities impacting communities through entrepreneurship: A case study of student enterprise from a South African university

SOTL in the South
The role of a university education is to transform and develop communities through the production of academically competent graduates and research, as well as through knowledge creation.
Rosaline Sebolao
doaj   +1 more source