Results 81 to 90 of about 19,313 (263)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

‘Translating’ Classics for Generations Z and Alpha

The Journal of Classics Teaching
This paper presents a public outreach program developed by the Department of Classics at the University of Florida to introduce school-age children to Classics.
Eleni Bozia, Anastasia Pantazopoulou, Anthony J. Smith   +2 more
doaj   +1 more source

Museet – en fristad för tvärvetenskaplig forskning eller lågprisakademi?

Kulturella Perspektiv, 2013
Most scholars within the humanities not employed at a university or university college, are engaged as researchers at museums, archives or libraries.
Andreas Nyblom
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Operative and predicative forms of knowledge [PDF]

Investigações em Ensino de Ciências, 2012
The major aim of this paper is to approach ideas that stem from lessons I have been able to learn from the most diverse types of experiences, especially from the research on psychology and on the and didactics of mathematics in which I have been ...
Gérard Vergnaud
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

ENGAGED RESEARCH-LED TEACHING: COMPOSING COLLECTIVE INQUIRY WITH DIGITAL METHODS AND DATA

Digital Culture & Education, 2022
This article examines the organisation of collaborative digital methods and data projects in the context of engaged research-led teaching in the humanities.
Jonathan Gray, Liliana Bounegru, Richard Rogers, Tommaso Venturini, Donato Ricci, Axel Meunier, Michele Mauri, Sabine Niederer, Natalia Sánchez Querubín, Marc Tuters, Lucy Kimbell, Anders Kristian Munk   +11 more
doaj  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The humanities impacting communities through entrepreneurship: A case study of student enterprise from a South African university

SOTL in the South
The role of a university education is to transform and develop communities through the production of academically competent graduates and research, as well as through knowledge creation.
Rosaline Sebolao
doaj   +1 more source