Results 61 to 70 of about 1,183,219 (205)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Disciplined: Using educational studies to analyse 'Humanities Computing' [PDF]
, 2006 Humanities Computing is an emergent field. The activities described as 'Humanities Computing' continue to expand in number and sophistication, yet no concrete definition of the field exists, and there are few academic departments that specialize in this ...
Terras, M
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Arts and Humanities Literature: Bibliometric Characteristics of Contributions by Turkish Authors [PDF]
, 2006 Scholarly communication in arts and humanities differs from that in the sciences. Arts and humanities scholars rely primarily on monographs as amedium of publication whereas scientists consider articles that appear in scholarly journals as the single ...
Al, Umut +2 more
core +2 more sources
Humanities, Science, and Technology
, 1986 Application instructions and forms for humanities, science, and technology ...
National Endowment for the Humanities, Division of Research Programs
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Using Programming Environments for Academic Research and Writing
GromaDeveloper tools, such as code editors, markup languages, and revision control have a greater range of functions than word processors. As a scholar engaged in both Digital Humanities and the FOSS community, I have become increasingly interested in how ...
Morgan Lemmer-Webber
doaj +1 more source
Humanities, Science, and Technology
, 1983 Application instructions and forms for humanities, science, and technology ...
National Endowment for the Humanities, Division of Research Programs
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source