Results 51 to 60 of about 1,183,219 (205)
W sprawie polityczności polskiej humanistyki
Teksty Drugie, 2017 How political are the humanities in Poland today? Kuziak examines the possibilities and limitations of this question in the discourse of humanities scholars.
Michał Kuziak
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A literature review in digital humanities computing [PDF]
, 2007 The research start from the necessity to define with clarity what is digital humanities considering that digital humanities comprise the study of what happens when computers are as a means of solving humanist’s information problems.
Rinnovati, Laura
core +1 more source
Teksty Drugie, 2017 Tabaszewska presents the concept of ancillary literary studies within the context of debates on the humanities’ function and goals. She proposes to view literary scholarship, and the humanities more broadly, as a sphere in which the autonomy of research ...
Justyna Tabaszewska
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Frontiers in EducationThis Perspective examines the position of the humanities in Arab higher education and argues that the emergence of critical humanities in the region should be understood as an epistemic and institutional response to the conditions that shape knowledge ...
Badrane Benlahcene
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Towards a comprehensive narrative and response to COVID-19 in Southeast Asia
Social Sciences and Humanities Open, 2020 The dominant narrative of the COVID-19 pandemic in Southeast Asia barely gives attention to the many social and cultural dimensions of the crisis, and humanities and social science experts remain at the margins of containment decisions.
Rosalia Sciortino, Fabio Saini
doaj +1 more source