Results 111 to 120 of about 1,208,108 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

From a Feminist Ethic of Care to a Total Learning Experience: Co-creating Knowledge with Student Researchers on the AdArchive Project

Radical Teacher
This paper uses the example of a two-year Social Sciences and Humanities Research Council (SSHRC) -funded research project at a small regional college in Canada to discuss the difference that research assistant opportunities can make for undergraduate ...
Jana Smith Elford, Michelle Meagher, Wolfgang Edwards Van Muijen, Tiffany Braun   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Interpretive Research:Humanities, Science, and Technology

, 1990
Application instructions and forms for humanities, science, and technology ...
National Endowment for the Humanities, Division of Research Programs
core   +1 more source

Modeling Textual Emotions in Literary Fiction

Digital Humanities in the Nordic and Baltic Countries Publications
This paper explores how finetuned transformer models can be used to examine the vast and underexplored emotional-historical dimensions of literary history.
Kirstine Nielsen Degn, Alexander Conroy, Xiaoyuan Jiang, Ali Al-Laith, Jens Bjerring-Hansen, Tanya Karoli Christensen, Ingo Zettler, Daniel Hershcovich   +7 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Making and interpreting: digital humanities as embodied action

Humanities & Social Sciences Communications
Digital technology has created new spaces, new realities and new ways of life, which have changed the way people perceive and recognise the world. In particular, the production, dissemination and reception methods of literature and art have been impacted
Zhiqing Zhang, Wanyi Song, Peng Liu
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

‘Translating’ Classics for Generations Z and Alpha

The Journal of Classics Teaching
This paper presents a public outreach program developed by the Department of Classics at the University of Florida to introduce school-age children to Classics.
Eleni Bozia, Anastasia Pantazopoulou, Anthony J. Smith   +2 more
doaj   +1 more source