Results 111 to 120 of about 338,793 (308)
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Introducing citizen inquiry [PDF]
, 2017 The term ‘citizen inquiry’ was coined to describe ways that members of the public can learn by initiating or joining shared inquiry-led scientific investigations (Sharples et al., 2013).
Herodotou, Christothea +2 more
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Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Modeling Textual Emotions in Literary Fiction
Digital Humanities in the Nordic and Baltic Countries PublicationsThis paper explores how finetuned transformer models can be used to examine the vast and underexplored emotional-historical dimensions of literary history.
Kirstine Nielsen Degn +7 more
doaj +1 more source
Change of Paradigm: From Individual to Community-Based Scholarship
Humanist Studies & The Digital Age, 2015 The title does not refer to the application of knowledge through faculty engagement in community-based research, teaching and service – something that is usually understood as community-engaged scholarship. The change of paradigm referred to in the title
Massimo Riva
doaj +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Making and interpreting: digital humanities as embodied action
Humanities & Social Sciences CommunicationsDigital technology has created new spaces, new realities and new ways of life, which have changed the way people perceive and recognise the world. In particular, the production, dissemination and reception methods of literature and art have been impacted
Zhiqing Zhang, Wanyi Song, Peng Liu
doaj +1 more source
‘Translating’ Classics for Generations Z and Alpha
The Journal of Classics TeachingThis paper presents a public outreach program developed by the Department of Classics at the University of Florida to introduce school-age children to Classics.
Eleni Bozia +2 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source