Results 121 to 130 of about 1,183,219 (205)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Interpretive Research, Collaborative Projects, Archaeology Projects, Humanities, Science, and Technology

open access: yes, 1996
Application instructions and forms for interpretive research ...
National Endowment for the Humanities, Division of Research Programs
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

Topic Modeling for Humanities Research

open access: yes, 2013
Topic Modeling for Humanities Research, a one-day workshop directed by Assistant Director of MITH Dr. Jennifer Guiliano, received a Level 1 Digital Humanities start up from the National Endowment for the Humanities on April 19, 2011.
Maryland Institute for Technology in the Humanities   +1 more
core   +1 more source

Humanistyka wobec koncepcji ‘kulturynatury’

open access: yesTeksty Drugie, 2017
Rewers tackles two debates concerning key issues in the humanities today: 1) the axis that connects the stance of the researcher ‘close to death’ as well as close to birth, and 2) contemplation as a research activity and action.
Ewa Rewers
doaj  

Utah Humanities Research Foundation correspondence, 1947-1950

open access: yes, 1947
A set of letters dated 1947 to 1950 related to the work of the Utah Humanities Research Foundation, particularly the publication of articles in the Utah Humanities Review and Western Humanities Review.
Utah Humanities Research Foundation; Lee, Hector, 1908-1992; Bentley, Harold W.; Polland, Harold F.; Mulder, William
core  

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

Humanities, Vol. 9, Num. 6, November/December 1988

open access: yes, 1988
Featured story: Public Humanities ...
National Endowment for the Humanities, Office of Publications
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Utah Humanities Research Foundation correspondence, 1950-1952

open access: yes, 1947
A set of letters dated 1947 to 1950 related to the work of the Utah Humanities Research Foundation, particularly the publication of articles in the Utah Humanities Review and Western Humanities Review.
Utah Humanities Research Foundation; Lee, Hector, 1908-1992; Bentley, Harold W.; Folland, Harold F.; Mulder, William
core  

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