Results 121 to 130 of about 338,793 (308)

Operative and predicative forms of knowledge [PDF]

Investigações em Ensino de Ciências, 2012
The major aim of this paper is to approach ideas that stem from lessons I have been able to learn from the most diverse types of experiences, especially from the research on psychology and on the and didactics of mathematics in which I have been ...
Gérard Vergnaud
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

ENGAGED RESEARCH-LED TEACHING: COMPOSING COLLECTIVE INQUIRY WITH DIGITAL METHODS AND DATA

Digital Culture & Education, 2022
This article examines the organisation of collaborative digital methods and data projects in the context of engaged research-led teaching in the humanities.
Jonathan Gray, Liliana Bounegru, Richard Rogers, Tommaso Venturini, Donato Ricci, Axel Meunier, Michele Mauri, Sabine Niederer, Natalia Sánchez Querubín, Marc Tuters, Lucy Kimbell, Anders Kristian Munk   +11 more
doaj  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The humanities impacting communities through entrepreneurship: A case study of student enterprise from a South African university

SOTL in the South
The role of a university education is to transform and develop communities through the production of academically competent graduates and research, as well as through knowledge creation.
Rosaline Sebolao
doaj   +1 more source

Vital Signs: Metro Boston's Arts and Cultural Nonprofits 1999 and 2004 [PDF]

, 2007
Examines four "vital signs," or categories of data, to gauge the health of the area's arts and cultural nonprofit organizations in 1999-2004: a supportive environment, an innovative marketplace, an engaged audience, and the right-sized ...
Ann McQueen, Susan Nelson
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Practice-Led Research and the Engagement With Truth [PDF]

, 2006
This paper offers the thesis that practice-led research in art and design should propose changes to those relations of knowledge that currently ensure the integrity of practice and the neutrality and objectivity of theory.
Quinn, Malcolm
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The role of school history in helping young people to navigate their future at a time of climate crisis

History Education Research Journal
The need to prepare school students to respond to the climate and environmental crises is rapidly rising up educational agendas nationally and internationally, but the role of the humanities, and particularly history, is often marginalised.
doaj   +2 more sources